Hypoxia is implicated in many aspects of tumor development, angiogenesis, and growth in
many different tumors. Brain tumors, particularly the highly aggressive glioblastoma …

Abstract Models that recapitulate the complexity of human tumors are urgently needed to
develop more effective cancer therapies. We report a bank of human patient-derived xenografts …

Introduction Hypoxia inducible factor-1α (HIF-1α) regulates vascular endothelial growth
factor (VEGF), the presumed principal mediator of angiogenesis in malignant gliomas, under …

… Carolina Neurosurgery and Spine: Anthony L. Asher, MD Medical University of South Carolina:
Sunil J. Patel, … Laske, MD University of Utah Medical Center: Randy L. Jensen, MD, Ph.D. …

BACKGROUND. Regions of hypoxia within glioblastoma multiforme (GBM) are common and
may influence a tumor's aggressiveness, response to treatment, and the patient's overall …

Despite extensive efforts in research and therapeutics, achieving longer survival for patients
with glioblastoma (GBM) remains a formidable challenge. Furthermore, because of rapid …

OBJECTIVE: Subependymomas are slow-growing, benign tumors usually found incidentally
in the fourth ventricle at autopsy. They are typically associated with the ventricular system …

Purpose of Review This review will discuss the role of several key players in glioma
classification and biology, namely isocitrate dehydrogenase 1 and 2 (IDH1/2), alpha thalassemia/…

Background Measures of tumor vascularity and hypoxia have been correlated with glioma
grade and outcome. Dynamic contrast-enhanced (DCE) MRI can noninvasively map tumor …

Object. Benign meningiomas have been shown to be equally well controlled with single-dose
radiosurgery (15 Gy) and fractionated doses of 54 Gy in 30 fractions after adequate follow …