Activating mutations in ALK provide a therapeutic target in neuroblastoma

RE George, T Sanda, M Hanna, S Fröhling, WL Ii… - Nature, 2008 - nature.com
Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts
for approximately 15% of all deaths due to childhood cancer 1 . High-risk neuroblastomas …

[PDF][PDF] CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer

…, KK Wong, GC Yuan, NS Gray, RA Young, RE George - Cell, 2014 - cell.com
The MYC oncoproteins are thought to stimulate tumor cell growth and proliferation through
amplification of gene transcription, a mechanism that has thwarted most efforts to inhibit MYC …

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

…, W Kim, S Tang, P Sliz, P Santisteban, RE George… - Nature, 2018 - nature.com
N 6 -methyladenosine (m 6 A) modification of mRNA is emerging as an important regulator of
gene expression that affects different developmental and biological processes, and altered …

[PDF][PDF] Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

…, AR Aref, DA Barbie, JE Bradner, RE George… - Cancer cell, 2014 - cell.com
Small cell lung cancer (SCLC) is an aggressive disease with high mortality, and the identification
of effective pharmacological strategies to target SCLC biology represents an urgent …

[HTML][HTML] Giotto: a toolbox for integrative analysis and visualization of spatial expression data

…, H Li, K Liu, Y Fu, T Zhao, A Sarkar, F Bao, RE George… - Genome biology, 2021 - Springer
Spatial transcriptomic and proteomic technologies have provided new opportunities to
investigate cells in their native microenvironment. Here we present Giotto, a comprehensive and …

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors

…, R Volckmann, MM Van Noesel, RE George… - Nature …, 2015 - nature.com
Whole-genome sequencing detected structural rearrangements of TERT in 17 of 75 high-stage
neuroblastomas, with five cases resulting from chromothripsis. Rearrangements were …

The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

…, LCW Vredeveld, RE George… - Genes & …, 2008 - genesdev.cshlp.org
VHL, NF-1, c-Ret, and Succinate Dehydrogenase Subunits B and D act on a developmental
apoptotic pathway that is activated when nerve growth factor (NGF) becomes limiting for …

[PDF][PDF] Activated ALK collaborates with MYCN in neuroblastoma pathogenesis

…, D Helman, H Feng, RA Stewart, W Wang, RE George… - Cancer cell, 2012 - cell.com
Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by
mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic …

[PDF][PDF] The ALKF1174L mutation potentiates the oncogenic activity of MYCN in neuroblastoma

…, ADJ Pearson, SA Eccles, L Chesler, RE George - Cancer cell, 2012 - cell.com
The ALK F1174L mutation is associated with intrinsic and acquired resistance to crizotinib
and cosegregates with MYCN in neuroblastoma. In this study, we generated a mouse model …

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy

TR Webb, J Slavish, RE George, AT Look… - Expert review of …, 2009 - Taylor & Francis
Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms – the most …