User profiles for Rani Sarkis

Rani Sarkis MD, MSc.

Brigham and Women's Hospital, Harvard Medical School
Verified email at partners.org
Cited by 1939

[HTML][HTML] Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease

…, D Grün, AA Kroshilina, D Dionne, RA Sarkis… - Nature …, 2020 - nature.com
The extent of microglial heterogeneity in humans remains a central yet poorly explored question
in light of the development of therapies targeting this cell type. Here, we investigate the …

Association of epileptiform abnormalities and seizures in Alzheimer disease

AD Lam, RA Sarkis, KR Pellerin, J Jing, BA Dworetzky… - Neurology, 2020 - AAN Enterprises
Objective To examine the relationship between scalp EEG biomarkers of hyperexcitability in
Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical …

Expert-level automated sleep staging of long-term scalp electroencephalography recordings using deep learning

…, H Sun, KR Pellerin, M Pavlova, RA Sarkis… - Sleep, 2020 - academic.oup.com
Study Objectives Develop a high-performing, automated sleep scoring algorithm that can be
applied to long-term scalp electroencephalography (EEG) recordings. Methods Using a …

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations: A Report of the American Neuropsychiatric …

RA Sarkis, MJ Coffey, JJ Cooper… - The Journal of …, 2019 - Am Neuropsych Assoc
Objective: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune
disorder characterized by prominent neuropsychiatric symptoms. Given the nature of its …

Clinical and neurophysiologic characteristics of unprovoked seizures in patients diagnosed with dementia

RA Sarkis, BC Dickerson, AJ Cole… - The Journal of …, 2016 - Am Neuropsych Assoc
Seizures are a common comorbid condition in patients with dementia, but their characteristics
have been poorly described. The authors performed a retrospective chart review using ICD…

Autonomic changes following generalized tonic clonic seizures: an analysis of adult and pediatric patients with epilepsy

RA Sarkis, S Thome-Souza, MZ Poh, N Llewellyn… - Epilepsy research, 2015 - Elsevier
Objective Sudden unexpected death in epilepsy (SUDEP) is the most common cause of
mortality directly related to epilepsy. Its incidence is higher in adult patients and its …

Seizure outcomes following multilobar epilepsy surgery

RA Sarkis, L Jehi, IM Najm, P Kotagal… - Epilepsia, 2012 - Wiley Online Library
Purpose: Outcomes following unilobar surgeries for refractory epilepsy have been well
described. However, little is known about long‐term seizure outcomes following multilobar …

[HTML][HTML] Prospective study of a multimodal convulsive seizure detection wearable system on pediatric and adult patients in the epilepsy monitoring unit

…, F Mohammadpour-Touserkani, RA Sarkis… - Frontiers in …, 2021 - frontiersin.org
Background: Using machine learning to combine wrist accelerometer (ACM) and electrodermal
activity (EDA) has been shown effective to detect primarily and secondarily generalized …

Noninvasive detection of hippocampal epileptiform activity on scalp electroencephalogram

M Abou Jaoude, CS Jacobs, RA Sarkis, J Jing… - JAMA …, 2022 - jamanetwork.com
Importance The hippocampus is a highly epileptogenic brain region, yet over 90% of hippocampal
epileptiform activity (HEA) cannot be identified on scalp electroencephalogram (EEG) …

Video-based detection of generalized tonic-clonic seizures using deep learning

Y Yang, RA Sarkis, R El Atrache… - IEEE Journal of …, 2021 - ieeexplore.ieee.org
Timely detection of seizures is crucial to implement optimal interventions, and may help
reduce the risk of sudden unexpected death in epilepsy (SUDEP) in patients with generalized …