Recombination-dependent DNA replication, often called break-induced replication (BIR), was
initially invoked to explain recombination events in bacteriophage but it has recently been …

Recent human decedent model studies 1 , 2 and compassionate xenograft use 3 have explored
the promise of porcine organs for human transplantation. To proceed to human studies, …

Harnessing CRISPR-Cas9 technology provides an unprecedented ability to modify
genomic loci via DNA double-strand break (DSB) induction and repair. We analyzed …

Recent high-resolution genome analyses of cancer and other diseases have revealed the
occurrence of microhomology-mediated chromosome rearrangements and copy number …

DNA sequences that form secondary structures or bind protein complexes are known barriers
to replication and potential inducers of genome instability. In order to determine which …

Several molecular mechanisms have been proposed to explain trinucleotide repeat
expansions. Here we show that in yeast srs2Δ cells, CTG repeats undergo both expansions and …

Adenylosuccinate synthetase (AdSS) catalyses the Mg 2+ dependent formation of adenylosuccinate
from IMP and aspartate, the reaction being driven by the hydrolysis of GTP to GDP. …

Trinucleotide repeats are a source of genome instability, causing replication fork stalling,
chromosome fragility, and impaired repair. Specialized helicases play an important role in …

Hypoxanthine guanine phosphoribosyltransferases (HGPRTs) catalyze the conversion of 6‐oxopurine
bases to their respective nucleotides, the phosphoribosyl group being derived …

Double-strand DNA breaks occur upon exposure of cells to ionizing radiation and certain
chemical agents or indirectly through replication fork collapse at DNA damage sites. If left …