[HTML][HTML] Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
Neutralizing antibodies that target the receptor-binding domain (RBD) of the SARS-CoV-2
spike protein are among the most promising approaches against COVID-19 1 , 2 . A bispecific …
spike protein are among the most promising approaches against COVID-19 1 , 2 . A bispecific …
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
…, H Marcotte, A Piralla, M Pedotti, R De Gasparo… - Science …, 2023 - science.org
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development …
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued development …
The hit-and-return system enables efficient time-resolved serial synchrotron crystallography
We present a ‘hit-and-return’ (HARE) method for time-resolved serial synchrotron crystallography
with time resolution from milliseconds to seconds or longer. Timing delays are set …
with time resolution from milliseconds to seconds or longer. Timing delays are set …
[HTML][HTML] Machine learning analyses of antibody somatic mutations predict immunoglobulin light chain toxicity
…, M Matkovic, J Sgrignani, R De Gasparo… - Nature …, 2021 - nature.com
In systemic light chain amyloidosis (AL), pathogenic monoclonal immunoglobulin light chains
(LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial …
(LC) form toxic aggregates and amyloid fibrils in target organs. Prompt diagnosis is crucial …
Targeting a Large Active Site: Structure‐Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase
R De Gasparo, O Halgas, D Harangozo… - … A European Journal, 2019 - Wiley Online Library
Trypanothione reductase (TR) plays a key role in the unique redox metabolism of trypanosomatids,
the causative agents of human African trypanosomiasis (HAT), Chagas’ disease, and …
the causative agents of human African trypanosomiasis (HAT), Chagas’ disease, and …
Biological Evaluation and X‐ray Co‐crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of …
R De Gasparo, E Brodbeck‐Persch, S Bryson… - …, 2018 - Wiley Online Library
The tropical diseases human African trypanosomiasis, Chagas disease, and the various forms
of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa …
of leishmaniasis are caused by parasites of the family of trypanosomatids. These protozoa …
[HTML][HTML] Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2
…, J Muri, H Marcotte, A Piralla, M Pedotti, R De Gasparo… - bioRxiv, 2022 - ncbi.nlm.nih.gov
Emergence of SARS-CoV-2 variants diminishes the efficacy of vaccines and antiviral
monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens …
monoclonal antibodies. Continued development of immunotherapies and vaccine immunogens …
Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology
…, R Corbellari, L Simonelli, R De Gasparo… - Global …, 2023 - Wiley Online Library
Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment
of numerous infectious diseases. However, their neutralization potency is often rapidly lost …
of numerous infectious diseases. However, their neutralization potency is often rapidly lost …
A Convenient Palladium-Catalyzed Azaindole Synthesis
R De Gasparo, P Lustenberger, C Mathes, T Schlama… - Synlett, 2015 - thieme-connect.com
… Raoul De Gasparo … 3d de Mattos MC, Alatorre-Santamaria S, Gotor-Fernandez V,
Gotor V. Synthesis 2007; 2149 … 3d de Mattos MC, Alatorre-Santamaria S, Gotor-Fernandez …
Gotor V. Synthesis 2007; 2149 … 3d de Mattos MC, Alatorre-Santamaria S, Gotor-Fernandez …
Publisher Correction: Bispecific IgG neutralizes SARS-CoV-2 variants and prevents escape in mice
R De Gasparo, M Pedotti, L Simonelli, P Nickl… - Nature, 2021 - nature.com
… Raoul De Gasparo … In this Article, authors Raoul De Gasparo and Mattia Pedotti should
not be linked to affiliation 15, ‘Howard Hughes Medical Institute, The Rockefeller University …
not be linked to affiliation 15, ‘Howard Hughes Medical Institute, The Rockefeller University …