Inositol-requiring enzyme 1 (IRE1) is a proximal endoplasmic reticulum (ER) stress sensor
and a central mediator of the unfolded protein response. In a human glioma model, inhibition …

Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor
aggressiveness. Evidence suggests that the endoplasmic reticulum ( ER ), a major site for protein …

In solid tumors, cancer cells subjected to ischemic conditions trigger distinct signaling pathways
contributing to angiogenic stimulation and tumor development. Characteristic features of …

Purpose: CD90 (Thy-1) is a glycophosphatidylinositol-anchored glycoprotein considered as
a surrogate marker for a variety of stem cells, including glioblastoma (GBM) stem cells (GSC)…

We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1)
to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM…

Growing evidence supports a role for the unfolded protein response (UPR) in carcinogenesis;
however, the precise molecular mechanisms underlying this phenomenon remain elusive. …

IRE1α is an endoplasmic reticulum (ER)-resident transmembrane signaling protein and a
cellular stress sensor. The protein harbors a cytosolic dual kinase/endoribonuclease activity …

Background Epidermal growth factor (EGF) receptors contribute to the development of
malignant glioma. Here we considered the possible implication of the EGFR ligand epiregulin (…

Kinesin motor proteins exert essential cellular functions in all eukaryotes. They control mitosis,
migration and intracellular transport through interaction with microtubules. Small molecule …

10.7554/eLife.13887.001 The extracellular matrix (ECM) plays an instrumental role in
determining the spatial orientation of epithelial polarity and the formation of lumens in glandular …