[HTML][HTML] A potentially abundant junctional RNA motif stabilized by m6A and Mg2+
…, SH Choi, MA Schumacher, R Plangger… - Nature …, 2018 - nature.com
N 6 -Methyladenosine (m 6 A) is an abundant post-transcriptional RNA modification that
influences multiple aspects of gene expression. In addition to recruiting proteins, m 6 A can …
influences multiple aspects of gene expression. In addition to recruiting proteins, m 6 A can …
[HTML][HTML] Eukaryotic translation elongation is modulated by single natural nucleotide derivatives in the coding sequences of mRNAs
…, D Köstner, K Faserl, F Nußbaumer, R Plangger… - Genes, 2019 - mdpi.com
RNA modifications are crucial factors for efficient protein synthesis. All classes of RNAs that
are involved in translation are modified to different extents. Recently, mRNA modifications …
are involved in translation are modified to different extents. Recently, mRNA modifications …
Aromatic 19F–13C TROSY—[19F, 13C]‐Pyrimidine Labeling for NMR Spectroscopy of RNA
F Nußbaumer, R Plangger, M Roeck… - Angewandte Chemie …, 2020 - Wiley Online Library
We present the access to [5‐ 19 F, 5‐ 13 C]‐uridine and ‐cytidine phosphoramidites for the
production of site‐specifically modified RNAs up to 65 nucleotides (nts). The amidites were …
production of site‐specifically modified RNAs up to 65 nucleotides (nts). The amidites were …
Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site
CC Chu, R Plangger, C Kreutz… - Nucleic acids …, 2019 - academic.oup.com
The HIV-1 Rev response element (RRE) RNA element mediates the nuclear export of intron
containing viral RNAs by forming an oligomeric complex with the viral protein Rev. Stem IIB …
containing viral RNAs by forming an oligomeric complex with the viral protein Rev. Stem IIB …
Advances in RNA labeling with trifluoromethyl groups
C Eichler, M Himmelstoß, R Plangger… - … A European Journal, 2023 - Wiley Online Library
Fluorine labeling of ribonucleic acids (RNA) in conjunction with 19 F NMR spectroscopy has
emerged as a powerful strategy for spectroscopic analysis of RNA structure and dynamics, …
emerged as a powerful strategy for spectroscopic analysis of RNA structure and dynamics, …
[HTML][HTML] Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA
…, M Palasser, SV Heel, J Vušurović, R Plangger… - Nature …, 2020 - nature.com
Nuclear export complexes composed of rev response element (RRE) ribonucleic acid (RNA)
and multiple molecules of rev protein are promising targets for the development of …
and multiple molecules of rev protein are promising targets for the development of …
Contribution of tRNA sequence and modifications to the decoding preferences of E. coli and M. mycoides tRNAGlyUCC for synonymous glycine codons
…, K Bartosik, K Erharter, R Plangger… - Nucleic Acids …, 2024 - academic.oup.com
tRNA superwobbling, used by certain bacteria and organelles, is an intriguing decoding
concept in which a single tRNA isoacceptor is used to decode all synonymous codons of a four-…
concept in which a single tRNA isoacceptor is used to decode all synonymous codons of a four-…
[HTML][HTML] m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB
CC Chu, B Liu, R Plangger, C Kreutz, HM Al-Hashimi - PLoS One, 2019 - journals.plos.org
N 6 -methyladenosine (m 6 A) is a ubiquitous RNA post-transcriptional modification found in
coding as well as non-coding RNAs. m 6 A has also been found in viral RNAs where it is …
coding as well as non-coding RNAs. m 6 A has also been found in viral RNAs where it is …
5‐Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson–Crick like cmo5U‐G Base Pairs
E Strebitzer, A Rangadurai, R Plangger… - … A European Journal, 2018 - Wiley Online Library
Watson–Crick like G‐U mismatches with tautomeric G enol or U enol bases can evade fidelity
checkpoints and thereby contribute to translational errors. The 5‐oxyacetic acid uridine (…
checkpoints and thereby contribute to translational errors. The 5‐oxyacetic acid uridine (…
Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing
R Plangger, MA Juen, TP Hoernes… - Nucleic Acids …, 2019 - academic.oup.com
Although group II intron ribozymes are intensively studied the question how structural dynamics
affects splicing catalysis has remained elusive. We report for the first time that the group …
affects splicing catalysis has remained elusive. We report for the first time that the group …