[HTML][HTML] A potentially abundant junctional RNA motif stabilized by m6A and Mg2+

…, SH Choi, MA Schumacher, R Plangger… - Nature …, 2018 - nature.com
N 6 -Methyladenosine (m 6 A) is an abundant post-transcriptional RNA modification that
influences multiple aspects of gene expression. In addition to recruiting proteins, m 6 A can …

[HTML][HTML] Eukaryotic translation elongation is modulated by single natural nucleotide derivatives in the coding sequences of mRNAs

…, D Köstner, K Faserl, F Nußbaumer, R Plangger… - Genes, 2019 - mdpi.com
RNA modifications are crucial factors for efficient protein synthesis. All classes of RNAs that
are involved in translation are modified to different extents. Recently, mRNA modifications …

Aromatic 19F–13C TROSY—[19F, 13C]‐Pyrimidine Labeling for NMR Spectroscopy of RNA

F Nußbaumer, R Plangger, M Roeck… - Angewandte Chemie …, 2020 - Wiley Online Library
We present the access to [5‐ 19 F, 5‐ 13 C]‐uridine and ‐cytidine phosphoramidites for the
production of site‐specifically modified RNAs up to 65 nucleotides (nts). The amidites were …

Dynamic ensemble of HIV-1 RRE stem IIB reveals non-native conformations that disrupt the Rev-binding site

CC Chu, R Plangger, C Kreutz… - Nucleic acids …, 2019 - academic.oup.com
The HIV-1 Rev response element (RRE) RNA element mediates the nuclear export of intron
containing viral RNAs by forming an oligomeric complex with the viral protein Rev. Stem IIB …

Advances in RNA labeling with trifluoromethyl groups

C Eichler, M Himmelstoß, R Plangger… - … A European Journal, 2023 - Wiley Online Library
Fluorine labeling of ribonucleic acids (RNA) in conjunction with 19 F NMR spectroscopy has
emerged as a powerful strategy for spectroscopic analysis of RNA structure and dynamics, …

[HTML][HTML] Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA

…, M Palasser, SV Heel, J Vušurović, R Plangger… - Nature …, 2020 - nature.com
Nuclear export complexes composed of rev response element (RRE) ribonucleic acid (RNA)
and multiple molecules of rev protein are promising targets for the development of …

Contribution of tRNA sequence and modifications to the decoding preferences of E. coli and M. mycoides tRNAGlyUCC for synonymous glycine codons

…, K Bartosik, K Erharter, R Plangger… - Nucleic Acids …, 2024 - academic.oup.com
tRNA superwobbling, used by certain bacteria and organelles, is an intriguing decoding
concept in which a single tRNA isoacceptor is used to decode all synonymous codons of a four-…

[HTML][HTML] m6A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB

CC Chu, B Liu, R Plangger, C Kreutz, HM Al-Hashimi - PLoS One, 2019 - journals.plos.org
N 6 -methyladenosine (m 6 A) is a ubiquitous RNA post-transcriptional modification found in
coding as well as non-coding RNAs. m 6 A has also been found in viral RNAs where it is …

5‐Oxyacetic Acid Modification Destabilizes Double Helical Stem Structures and Favors Anionic Watson–Crick like cmo5U‐G Base Pairs

E Strebitzer, A Rangadurai, R Plangger… - … A European Journal, 2018 - Wiley Online Library
Watson–Crick like G‐U mismatches with tautomeric G enol or U enol bases can evade fidelity
checkpoints and thereby contribute to translational errors. The 5‐oxyacetic acid uridine (…

Branch site bulge conformations in domain 6 determine functional sugar puckers in group II intron splicing

R Plangger, MA Juen, TP Hoernes… - Nucleic Acids …, 2019 - academic.oup.com
Although group II intron ribozymes are intensively studied the question how structural dynamics
affects splicing catalysis has remained elusive. We report for the first time that the group …