[HTML][HTML] Increased memory B cell potency and breadth after a SARS-CoV-2 mRNA boost

…, E Bednarski, V Ramos, S Zong, B Johnson, R Raspe… - Nature, 2022 - nature.com
The Omicron variant of SARS-CoV-2 infected many vaccinated and convalescent individuals
1 , 2 – 3 . Despite the reduced protection from infection, individuals who received three …

Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens

…, F Muenn, A Cho, S Zong, R Raspe… - Journal of Experimental …, 2022 - rupress.org
The SARS-CoV-2 pandemic prompted a global vaccination effort and the development of
numerous COVID-19 vaccines at an unprecedented scale and pace. As a result, current COVID…

Coregistered Spectral Optical Coherence Tomography and Two‐Photon Microscopy for Multimodal Near‐Instantaneous Deep‐Tissue Imaging

A Rakhymzhan, L Reuter, R Raspe, D Bremer… - Cytometry Part …, 2020 - Wiley Online Library
Two‐photon microscopy (2PM) has brought unique insight into the mechanisms underlying
immune system dynamics and function since it enables monitoring of cellular motility and …

[HTML][HTML] Antibody feedback regulates immune memory after SARS-CoV-2 mRNA vaccination

…, F Muecksch, A Cho, M Loewe, M Cipolla, R Raspe… - Nature, 2023 - nature.com
Feedback inhibition of humoral immunity by antibodies was first documented in 1909 1 .
Subsequent studies showed that, depending on the context, antibodies can enhance or inhibit …

Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans

…, M Canis, L Witte, B Johnson, R Raspe… - Journal of Experimental …, 2022 - rupress.org
Individuals who receive a third mRNA vaccine dose show enhanced protection against
severe COVID-19, but little is known about the impact of breakthrough infections on memory …

[HTML][HTML] The modular curriculum of medicine at the Charité Berlin–a project report based on an across-semester student evaluation

…, W Wurl, Y Roa-Romero, R Raspe… - GMS journal for …, 2019 - ncbi.nlm.nih.gov
Aim: The introduction of a reform clause into the German licensing laws for medical doctors
has enabled German faculties to pilot alternative designs for medical degree programmes. …

[HTML][HTML] Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

…, F Schmidt, Z Wang, A Cho, R Raspe… - Nature …, 2023 - nature.com
Waves of SARS-CoV-2 infection have resulted from the emergence of viral variants with
neutralizing antibody resistance mutations. Simultaneously, repeated antigen exposure has …

Increased potency and breadth of SARS-CoV-2 neutralizing antibodies after a third mRNA vaccine dose

…, E Bednarski, V Ramos, S Zong, B Johnson, R Raspe… - BioRxiv, 2022 - biorxiv.org
The omicron variant of SARS-CoV-2 infected very large numbers of SARS-CoV-2
vaccinated and convalescent individuals 1 – 3 . The penetrance of this variant in the antigen …

[PDF][PDF] Analysis of memory B cells identifies conserved neutralizing epitopes on the N-terminal domain of variant SARS-Cov-2 spike proteins

…, J DaSilva, E Bednarski, TB Tanfous, R Raspe… - Immunity, 2022 - cell.com
SARS-CoV-2 infection or vaccination produces neutralizing antibody responses that
contribute to better clinical outcomes. The receptor-binding domain (RBD) and the N-terminal …

[HTML][HTML] Memory B cell development elicited by mRNA booster vaccinations in the elderly

Z Wang, F Muecksch, R Raspe, F Johannsen… - Journal of Experimental …, 2023 - rupress.org
Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe
consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in a …