Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in …

MAIT cells are an unconventional T cell population that can be activated through both TCR-dependent
and TCR-independent mechanisms. Here, we examined the impact of …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by joint
destruction and severe morbidity. Methotrexate (MTX) is the standard first-line therapy of RA. …

Sepsis results in elevated adenosine in circulation. Extracellular adenosine triggers
immunosuppressive signaling via the A2a receptor (A2aR). Sepsis survivors develop persistent …

The aryl hydrocarbon receptor (AHR) is a transcription factor activated by ligand highly
expressed on T H 17 cells, and AHR-deficient CD4 + T cells have impaired production of IL-17A …

Precision medicine in immune-mediated inflammatory diseases (IMIDs) requires an
understanding of how cellular networks change following therapy. We describe a therapeutic atlas …

Epidemiological and experimental studies support the idea that helminth infections can induce
a protective effect against the development of autoimmune and allergic diseases. In this …

Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of
patients. Combining bulk and single-cell transcriptomics, quantitative histopathology, and in …

Rheumatoid arthritis (RA) is an autoimmune disease that causes joint destruction. Although
its etiology remains unknown, citrullinated proteins have been considered as an auto-…

Cellular immunity is critical for protection against tuberculosis, but its integrity is compromised
during undernutrition. The present study was designed to evaluate if the attenuated …