User profiles for Rasmus Agerholm
 | Rasmus AgerholmTechincal Universitey of Denmark Verified email at dtu.dk Cited by 107 |
The cIAP ubiquitin ligases sustain type 3 γδ T cells and ILC during aging to promote barrier immunity
J Rizk, UM Mörbe, R Agerholm, MV Baglioni… - Journal of Experimental …, 2023 - rupress.org
Early-life cues shape the immune system during adulthood. However, early-life signaling
pathways and their temporal functions are not well understood. Herein, we demonstrate that …
pathways and their temporal functions are not well understood. Herein, we demonstrate that …
STAT 3 but not STAT 4 is critical for γδT17 cell responses and skin inflammation
The transcription factors STAT 3 and STAT 4 are essential for lymphocyte differentiation and
function. Interleukin ( IL )‐17 producing γδ T (γδT17) cells are innate lymphocytes important …
function. Interleukin ( IL )‐17 producing γδ T (γδT17) cells are innate lymphocytes important …
Evolved to protect, designed to destroy: IL‐17‐producing γδ T cells in infection, inflammation, and cancer
R Agerholm, V Bekiaris - European Journal of Immunology, 2021 - Wiley Online Library
T cells of the gamma delta (γδ) lineage are evolutionary conserved from jawless to cartilaginous
and bony fish to mammals and represent the “swiss army knife” of the immune system …
and bony fish to mammals and represent the “swiss army knife” of the immune system …
[HTML][HTML] The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5
D Kadekar, R Agerholm, J Rizk… - The Journal of …, 2020 - Am Soc Clin Investig
IL-17–producing RORγt + γδ T cells (γδT17 cells) are innate lymphocytes that participate in
type 3 immune responses during infection and inflammation. Herein, we show that γδT17 …
type 3 immune responses during infection and inflammation. Herein, we show that γδT17 …
SMAC mimetics promote NIK-dependent inhibition of CD4+ TH17 cell differentiation
J Rizk, J Kaplinsky, R Agerholm, D Kadekar, F Ivars… - Science …, 2019 - science.org
Second mitochondria-derived activator of caspase (SMAC) mimetics (SMs) are selective
antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-κB …
antagonists of the inhibitor of apoptosis proteins (IAPs), which activate noncanonical NF-κB …
The immune checkpoint receptor associated phosphatases SHP‐1 and SHP‐2 are not required for γδT17 cell development, activation, or skin inflammation
D Kadekar, R Agerholm, MT Viñals… - European Journal of …, 2020 - Wiley Online Library
IL‐17‐producing gamma delta (γδT17) cells are innate lymphocytes critical for antibacterial
protection at barrier surfaces such as the skin but also highly pathogenic during inflammation…
protection at barrier surfaces such as the skin but also highly pathogenic during inflammation…
The neonatal microenvironment programs conventional and intestinal Tbet+ γδT17 cells through the transcription factor STAT5
Interleukin(IL)-17-producing RORγt + γδ T (γδT17) cells develop in the embryonic thymus
and participate in type 3 immune responses. Herein we show that γδT17 cells rapidly …
and participate in type 3 immune responses. Herein we show that γδT17 cells rapidly …
Type I interferon supports γδ T‐cell homeostasis and immunity through direct and indirect receptor signaling in mice
R Agerholm, D Kadekar, J Rizk… - European Journal of …, 2021 - Wiley Online Library
Interleukin (IL)‐17‐producing gamma delta (γδ) T (γδT17) cells are an essential part of innate
type 3 immunity against numerous pathogens. At the same time, a large body of evidence …
type 3 immunity against numerous pathogens. At the same time, a large body of evidence …
cIAP1/2 antagonization by SMAC mimetic induces non-canonical NF-κB mediated TH 17 cell homotypic interactions and increases their resistance to shear stress.
SMAC antagonization of cIAP1/2 in TH 17 cells upregulates cell adhesion and cytoskeleton
genes through the NIK-RelB and p52 axis. SMAC also increases the homotypic interactions …
genes through the NIK-RelB and p52 axis. SMAC also increases the homotypic interactions …
The cIAP ubiquitin ligases sustain type 3 γδ T and innate lymphoid cells during aging to allow normal cutaneous and mucosal responses
RORγt + γδ T cells, known as γδT17, are an innate-like subset of T cells that produce
interleukin (IL)-17A and initiate type 3 immune responses during infections or autoimmune …
interleukin (IL)-17A and initiate type 3 immune responses during infections or autoimmune …