Schizophrenia is one of the most widespread and complex mental disorders. To
characterize the impact of schizophrenia, we performed single-nucleus RNA sequencing (snRNA-seq) …

Abstract Evaluation of gene expression levels by reverse transcription quantitative real-time
PCR (RT-qPCR) has for many years been the favourite approach for discovering disease-…

Familial Parkinson disease (PD) is associated with rare genetic mutations, but the etiology
in most patients with sporadic (s)PD is largely unknown, and the basis for its progression to …

Parkinson's Disease (PD) and Multiple System Atrophy (MSA) are neurodegenerative diseases
characterized neuropathologically by alpha-synuclein accumulation in brain cells. This …

Single-cell RNA-seq (scRNA-seq) assays are being increasingly utilized to investigate specific
hypotheses in both basic biology and clinically-applied studies. The design of most such …

Aggregation of alpha-synuclein (α-syn) is considered to be the major pathological hallmark
and driving force of Multiple System Atrophy (MSA) and Parkinson's disease (PD). Immune …

Multiple system atrophy (MSA) is a rare disease with a fatal outcome. To date, little is known
about the molecular processes underlying disease development. Its clinical overlap with …

Mass spectrometry (MS)-based proteomics aims to characterize comprehensive proteomes
in a fast and reproducible manner. Here we present the narrow-window data-independent …

Introduction Ubiquitous naturally occurring autoantibodies (nAbs) against alpha-synuclein (α-syn)
may play important roles in the pathogenesis of Multiple System Atrophy (MSA) and …

Disruption of brain development early in life may underlie the neurobiology behind
schizophrenia. We have reported more immature synaptic spines in the frontal cortex (FC) of adult …