Single-cell, spatially resolved omics analysis of tissues is poised to transform biomedical
research and clinical practice. We have developed an open-source, computational histology …

Tumors systemically initiate metastatic niches in distant target metastatic organs. These
niches, composed of bone marrow–derived hematopoietic cells, provide permissive conditions …

A holistic understanding of tissue and organ structure and function requires the detection of
molecular constituents in their original three-dimensional (3D) context. Imaging mass …

CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or germline
mutants of model organisms. Key constraints in vivo remain the expression and delivery …

Alternative pre-mRNA splicing is a key molecular event that allows for protein diversity.
Through this process, a single gene increases its coding capacity by expressing several related …

Inflammation is inextricably associated with primary tumor progression. However, the contribution
of inflammation to tumor outgrowth in metastatic organs has remained underexplored. …

The progression of cancer to metastatic disease is a major cause of death. We identified miR-708
being transcriptionally repressed by polycomb repressor complex 2-induced H3K27 …

Metastatic tumors have been shown to establish permissive microenvironments for
metastases via recruitment of bone marrow–derived cells. Here, we show that metastasis-…

Vascular endothelial growth factor (VEGF) is overexpressed during the transition from prostate
intraepithelial neoplasia (PIN) to invasive carcinoma. We have mimicked such a process …

Background Different isoforms of VEGF-A (mainly VEGF 121 , VEGF 165 and VEGF 189 )
have been shown to display particular angiogenic properties in the generation of a functional …