User profiles for Ravindra K. Gupta

Ravindra Kumar Gupta

University of Cambridge
Verified email at cam.ac.uk
Cited by 25271

[HTML][HTML] Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity

…, IG Goodfellow, NJ Matheson, K Sato, RK Gupta - Nature, 2022 - nature.com
The SARS-CoV-2 Omicron BA.1 variant emerged in 2021 1 and has multiple mutations in its
spike protein 2 . Here we show that the spike protein of Omicron has a higher affinity for …

[HTML][HTML] SARS-CoV-2 variants, spike mutations and immune escape

…, AM Carabelli, B Jackson, RK Gupta… - Nature Reviews …, 2021 - nature.com
Although most mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
genome are expected to be either deleterious and swiftly purged or relatively neutral, a …

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

RK Gupta, S Abdul-Jawad, LE McCoy, HP Mok… - Nature, 2019 - nature.com
A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago 1
, 2 . The individual—who is known as the ‘Berlin patient’—underwent two allogeneic …

[HTML][HTML] SARS-CoV-2 B. 1.617. 2 Delta variant replication and immune evasion

…, L Piccoli, WS Barclay, P Rakshit, A Agrawal, RK Gupta - Nature, 2021 - nature.com
The B.1.617.2 (Delta) variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
was first identified in the state of Maharashtra in late 2020 and spread throughout India, …

[HTML][HTML] The biological and clinical significance of emerging SARS-CoV-2 variants

K Tao, PL Tzou, J Nouhin, RK Gupta… - Nature Reviews …, 2021 - nature.com
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …

The “silent” global burden of congenital cytomegalovirus

…, T Lazzarotto, SB Boppana, RK Gupta - Clinical microbiology …, 2013 - Am Soc Microbiol
Human cytomegalovirus (CMV) is a leading cause of congenital infections worldwide. In the
developed world, following the virtual elimination of circulating rubella, it is the commonest …

[PDF][PDF] Characterization of the enhanced infectivity and antibody evasion of Omicron BA. 2.75

…, X Niu, Q Gu, F Shao, X Hao, B Meng, RK Gupta… - Cell host & …, 2022 - cell.com
Recently emerged SARS-CoV-2 Omicron subvariant, BA.2.75, displayed a growth advantage
over circulating BA.2.38, BA.2.76, and BA.5 in India. However, the underlying mechanisms …

Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

…, RK Gupta… - Science, 2021 - science.org
Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50…

[HTML][HTML] SARS-CoV-2 variant evasion of monoclonal antibodies based on in vitro studies

…, DW Wright, BJ Willett, E Thomson, RK Gupta… - Nature Reviews …, 2023 - nature.com
Monoclonal antibodies (mAbs) offer a treatment option for individuals with severe COVID-19
and are especially important in high-risk individuals where vaccination is not an option. …

[HTML][HTML] FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

…, T Marjot, E Barnes, AM Moon, AS Barritt IV, RK Gupta… - Nature, 2023 - nature.com
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting
enzyme 2 (ACE2) 1 , could represent a new chemoprophylactic approach for …