User profiles for Ray Tobler

Ray Tobler

Evolution of Cultural Diversity Initiative, ANU
Verified email at anu.edu.au
Cited by 2750

Sequencing pools of individuals—mining genome-wide polymorphism data without big funding

C Schlötterer, R Tobler, R Kofler, V Nolte - Nature Reviews Genetics, 2014 - nature.com
The analysis of polymorphism data is becoming increasingly important as a complementary
tool to classical genetic analyses. Nevertheless, despite plunging sequencing costs, …

Aboriginal mitogenomes reveal 50,000 years of regionalism in Australia

R Tobler, A Rohrlach, J Soubrier, P Bover, B Llamas… - Nature, 2017 - nature.com
Aboriginal Australians represent one of the longest continuous cultural complexes known.
Archaeological evidence indicates that Australia and New Guinea were initially settled …

Ethics of DNA research on human remains: five globally applicable guidelines

…, A Szécsényi-Nagy, K Thangaraj, V Tiesler, R Tobler… - Nature, 2021 - nature.com
We are a group of archaeologists, anthropologists, curators and geneticists representing
diverse global communities and 31 countries. All of us met in a virtual workshop dedicated to …

A global environmental crisis 42,000 years ago

…, Y Souilmi, J Stevenson, Z Thomas, R Tobler… - Science, 2021 - science.org
Geological archives record multiple reversals of Earth’s magnetic poles, but the global
impacts of these events, if any, remain unclear. Uncertain radiocarbon calibration has limited …

Secondary contact and local adaptation contribute to genome‐wide patterns of clinal variation in Drosophila melanogaster

AO Bergland, R Tobler, J González… - Molecular …, 2016 - Wiley Online Library
Populations arrayed along broad latitudinal gradients often show patterns of clinal variation
in phenotype and genotype. Such population differentiation can be generated and …

[PDF][PDF] An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

Y Souilmi, ME Lauterbur, R Tobler, CD Huber… - Current Biology, 2021 - cell.com
The current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has
emphasized the vulnerability of human populations to novel viral pressures, despite the vast …

Massive Habitat-Specific Genomic Response in D. melanogaster Populations during Experimental Evolution in Hot and Cold Environments

R Tobler, SU Franssen, R Kofler… - Molecular biology …, 2014 - academic.oup.com
Experimental evolution in combination with whole-genome sequencing (evolve and
resequence [E&R]) is a promising approach to define the genotype–phenotype map and to …

[HTML][HTML] Genetic redundancy fuels polygenic adaptation in Drosophila

N Barghi, R Tobler, V Nolte, AM Jakšić, F Mallard… - PLoS …, 2019 - journals.plos.org
The genetic architecture of adaptive traits is of key importance to predict evolutionary
responses. Most adaptive traits are polygenic—ie, result from selection on a large number of …

[HTML][HTML] A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila

F Mallard, V Nolte, R Tobler, M Kapun, C Schlötterer - Genome biology, 2018 - Springer
Background Population genetic theory predicts that rapid adaptation is largely driven by
complex traits encoded by many loci of small effect. Because large-effect loci are quickly fixed in …

[HTML][HTML] A Genome-Wide, Fine-Scale Map of Natural Pigmentation Variation in Drosophila melanogaster

H Bastide, A Betancourt, V Nolte, R Tobler… - PLoS …, 2013 - journals.plos.org
Various approaches can be applied to uncover the genetic basis of natural phenotypic
variation, each with their specific strengths and limitations. Here, we use a replicated genome-…