[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells

…, K Crichton, TL Daigle, R Dalley, RA de Frates… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …

Classification of electrophysiological and morphological neuron types in the mouse visual cortex

…, N Dotson, T Egdorf, M Fisher, RA de Frates… - Nature …, 2019 - nature.com
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …

Classification of electrophysiological and morphological types in mouse visual cortex

…, N Dotson, T Egdorf, M Fisher, RA de Frates… - BioRxiv, 2018 - biorxiv.org
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To profile …

[HTML][HTML] Human neocortical expansion involves glutamatergic neuron diversification

…, T Casper, P Chong, K Crichton, R Dalley, R de Frates… - Nature, 2021 - nature.com
The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …

[PDF][PDF] Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons

…, RD Hodge, NL Jorstad, S Owen, R de Frates… - Neuron, 2021 - cell.com
In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5)
extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these neurons …

[PDF][PDF] h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex

…, TE Bakken, RD Hodge, P Chong, R de Frates… - Neuron, 2018 - cell.com
Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels more …

[HTML][HTML] A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits

JT Ting, B Kalmbach, P Chong, R De Frates… - Scientific reports, 2018 - nature.com
The powerful suite of available genetic tools is driving tremendous progress in understanding
mouse brain cell types and circuits. However, the degree of conservation in human …

Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons

…, T Casper, P Chong, K Crichton, R Dalley, R de Frates… - BioRxiv, 2020 - biorxiv.org
The neocortex is disproportionately expanded in human compared to mouse, both in its total
volume relative to subcortical structures and in the proportion occupied by supragranular …

Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons

…, T Casper, K Crichton, TL Daigle, R Dalley, R de Frates… - BioRxiv, 2020 - biorxiv.org
Neurons are frequently classified into distinct groups or cell types on the basis of structural,
physiological, or genetic attributes. To better constrain the definition of neuronal cell types, …

[HTML][HTML] Connecting single-cell transcriptomes to projectomes in mouse visual cortex

…, F Collman, T Daigle, T Dawes, R de Frates… - bioRxiv, 2023 - ncbi.nlm.nih.gov
The mammalian brain is composed of diverse neuron types that play different functional
roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of …