[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells
…, K Crichton, TL Daigle, R Dalley, RA de Frates… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …
or genetic attributes. To better constrain the definition of neuronal cell types, we …
Classification of electrophysiological and morphological neuron types in the mouse visual cortex
…, N Dotson, T Egdorf, M Fisher, RA de Frates… - Nature …, 2019 - nature.com
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To …
requires detailed characterization of individual neurons in multiple dimensions. To …
Classification of electrophysiological and morphological types in mouse visual cortex
…, N Dotson, T Egdorf, M Fisher, RA de Frates… - BioRxiv, 2018 - biorxiv.org
Understanding the diversity of cell types in the brain has been an enduring challenge and
requires detailed characterization of individual neurons in multiple dimensions. To profile …
requires detailed characterization of individual neurons in multiple dimensions. To profile …
[HTML][HTML] Human neocortical expansion involves glutamatergic neuron diversification
…, T Casper, P Chong, K Crichton, R Dalley, R de Frates… - Nature, 2021 - nature.com
The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …
in its total volume relative to subcortical structures and in the proportion occupied by …
[PDF][PDF] Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons
In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5)
extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these neurons …
extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these neurons …
[PDF][PDF] h-Channels contribute to divergent intrinsic membrane properties of supragranular pyramidal neurons in human versus mouse cerebral cortex
Gene expression studies suggest that differential ion channel expression contributes to
differences in rodent versus human neuronal physiology. We tested whether h-channels more …
differences in rodent versus human neuronal physiology. We tested whether h-channels more …
[HTML][HTML] A robust ex vivo experimental platform for molecular-genetic dissection of adult human neocortical cell types and circuits
JT Ting, B Kalmbach, P Chong, R De Frates… - Scientific reports, 2018 - nature.com
The powerful suite of available genetic tools is driving tremendous progress in understanding
mouse brain cell types and circuits. However, the degree of conservation in human …
mouse brain cell types and circuits. However, the degree of conservation in human …
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
…, T Casper, P Chong, K Crichton, R Dalley, R de Frates… - BioRxiv, 2020 - biorxiv.org
The neocortex is disproportionately expanded in human compared to mouse, both in its total
volume relative to subcortical structures and in the proportion occupied by supragranular …
volume relative to subcortical structures and in the proportion occupied by supragranular …
Toward an integrated classification of neuronal cell types: morphoelectric and transcriptomic characterization of individual GABAergic cortical neurons
…, T Casper, K Crichton, TL Daigle, R Dalley, R de Frates… - BioRxiv, 2020 - biorxiv.org
Neurons are frequently classified into distinct groups or cell types on the basis of structural,
physiological, or genetic attributes. To better constrain the definition of neuronal cell types, …
physiological, or genetic attributes. To better constrain the definition of neuronal cell types, …
[HTML][HTML] Connecting single-cell transcriptomes to projectomes in mouse visual cortex
The mammalian brain is composed of diverse neuron types that play different functional
roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of …
roles. Recent single-cell RNA sequencing approaches have led to a whole brain taxonomy of …