Therapies that target the synthesis of estrogen or the function of estrogen receptor(s) have
been developed to treat breast cancer. While these approaches have proven to be beneficial …

Human X‐box binding protein‐1 (XBP1) is an alternatively spliced transcription factor that
participates in the unfolded protein response (UPR), a stress‐signaling pathway that allows …

Since Cas was first identified as a highly phosphorylated 130 kilodalton protein that associated
with the v-Src and v-Crk-oncoproteins, considerable effort has been made to determine …

We have directly assessed the ability of interferon regulatory factor-1 (IRF-1) to act as a
tumor suppressor gene in human breast cancer cells and explored whether this suppressor …

Motivation: Significant efforts have been made to acquire data under different conditions and
to construct static networks that can explain various gene regulation mechanisms. However…

One-third of all estrogen receptor (ER)–positive breast tumors treated with endocrine
therapy fail to respond, and the remainder is likely to relapse in the future. Almost all data on …

The molecular mechanisms underlying the acquisition of resistance to the antiestrogen Faslodex
are poorly understood, although enhanced expression and activity of nuclear factor κB (…

Therapy resistance represents a clinical challenge for advanced non-small cell lung cancer (NSCLC),
which still remains an incurable disease. There is growing evidence that cancer-…

Antiestrogen therapy induces the unfolded protein response (UPR) in estrogen receptor-positive
(ER+) breast cancer. X-box binding protein 1 (XBP1), which exists in the …

Background One of the major goals in gene and protein expression profiling of cancer is to
identify biomarkers and build classification models for prediction of disease prognosis or …