User profiles for Rebecca Elyanow

Rebecca Elyanow

Adaptive Biotechnologies
Verified email at adaptivebiotech.com
Cited by 611

[HTML][HTML] Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels

…, Q DeGottardi, G Keitany, J Lu, A Vong, R Elyanow… - MedRxiv, 2020 - ncbi.nlm.nih.gov
T cells are involved in the early identification and clearance of viral infections and also
support the development of antibodies by B cells. This central role for T cells makes them a …

[HTML][HTML] T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity

R Elyanow, TM Snyder, SC Dalai, RM Gittelman… - JCI insight, 2022 - ncbi.nlm.nih.gov
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of
past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell …

The T-cell response to SARS-CoV-2 vaccination in inflammatory bowel disease is augmented with anti-TNF therapy

D Li, A Xu, E Mengesha, R Elyanow… - Inflammatory Bowel …, 2022 - academic.oup.com
Lay Summary T-cell and antibody responses to severe acute respiratory syndrome
coronavirus 2 vaccination in inflammatory bowel disease patients are poorly correlated. T-cell …

Identifying structural variants using linked-read sequencing data

R Elyanow, HT Wu, BJ Raphael - Bioinformatics, 2018 - academic.oup.com
Motivation Structural variation, including large deletions, duplications, inversions, translocations
and other rearrangements, is common in human and cancer genomes. A number of …

netNMF-sc: leveraging gene–gene interactions for imputation and dimensionality reduction in single-cell expression analysis

R Elyanow, B Dumitrascu, BE Engelhardt… - Genome …, 2020 - genome.cshlp.org
Single-cell RNA-sequencing (scRNA-seq) enables high-throughput measurement of RNA
expression in single cells. However, because of technical limitations, scRNA-seq data often …

Symptom burden and immune dynamics 6 to 18 months following mild severe acute respiratory syndrome coronavirus 2 infection (SARS-CoV-2): a case-control study

…, TB Onyango, KA Brokstad, R Elyanow… - Clinical Infectious …, 2023 - academic.oup.com
Background The burden and duration of persistent symptoms after nonsevere coronavirus
disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection …

AIRIVA: a deep generative model of adaptive immune repertoires

…, M Ilse, S Woodhouse, R Elyanow… - Machine Learning …, 2023 - proceedings.mlr.press
Recent advances in immunomics have shown that T-cell receptor (TCR) signatures can
accurately predict active or recent infection by leveraging the high specificity of TCR binding to …

STARCH: copy number and clone inference from spatial transcriptomics data

R Elyanow, R Zeira, M Land, BJ Raphael - Physical biology, 2021 - iopscience.iop.org
Tumors are highly heterogeneous, consisting of cell populations with both transcriptional
and genetic diversity. These diverse cell populations are spatially organized within a tumor, …

[HTML][HTML] Longitudinal analysis of T cell receptor repertoires reveals shared patterns of antigen-specific response to SARS-CoV-2 infection

…, TM Snyder, HJ Zahid, CL Carty, R Elyanow… - JCI insight, 2022 - ncbi.nlm.nih.gov
T cells play a prominent role in orchestrating the immune response to viral diseases, but
their role in the clinical presentation and subsequent immunity to SARS-CoV-2 infection …

Immunosequencing and epitope mapping reveal substantial preservation of the T cell immune response to Omicron generated by SARS-CoV-2 vaccines

…, BER Rubin, SC Dalai, K Patel, S Shafiani, R Elyanow… - MedRxiv, 2021 - medrxiv.org
The Omicron SARS-CoV-2 variant contains 34 mutations in the spike gene likely impacting
protective efficacy from vaccines. We evaluated the potential impact of these mutations on the …