Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and
neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal …

Microglia of the developing brain have unique functional properties but how their activation
states are regulated is poorly understood. Inflammatory activation of microglia in the still-…

Failed regeneration of myelin around neuronal axons following central nervous system damage
contributes to nerve dysfunction and clinical decline in various neurological conditions, …

The most prevalent neurological disorders of myelin include perinatal brain injury leading to
cerebral palsy in infants and multiple sclerosis in adults. Although these disorders have …

Maternal viral infection and immune response are known to increase the risk of altered
development of the foetal brain. Given the ongoing global pandemic of coronavirus disease 2019 …

The development and regeneration of myelin by oligodendrocytes, the myelin-forming cells
of the central nervous system (CNS), requires profound changes in cell shape that lead to …

Injury to the developing brain during the perinatal period often causes hypomyelination,
leading to clinical deficits for which there is an unmet therapeutic need. Dysregulation of …

Myelination of neuronal axons is a critical aspect of central nervous system development and
function. However, the fundamental cellular and molecular mechanisms influencing human …

Synapse loss correlates with cognitive decline in Alzheimer's disease (AD). Data from
mouse models suggests microglia are important for synapse degeneration, but direct human …