Reconstitution of an intact clock reveals mechanisms of circadian timekeeping

…, DC Ernst, M Fang, JG Palacios, RK Spangler… - Science, 2021 - science.org
INTRODUCTION Circadian clocks provide an internal representation of local time inside
cells and control the timing of gene expression in anticipation of sunrise and sunset. In …

Structural mimicry confers robustness in the cyanobacterial circadian clock

…, JG Palacios, C Sancar, DC Ernst, RK Spangler… - BioRxiv, 2020 - biorxiv.org
The histidine kinase SasA enhances robustness of circadian rhythms in the cyanobacterium
S. elongatus by temporally controlling expression of the core clock components, kaiB and …

Potassium rhythms couple the circadian clock to the cell cycle

…, LL Hansen, E Grunewald, AD Beale, RK Spangler… - bioRxiv, 2024 - biorxiv.org
Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases
the risk of infectious diseases, metabolic disorders, and cancer. Circadian rhythms couple to …

Regulation of the circadian clock in C. elegans by clock gene homologs kin-20 and lin-42

ML Lamberti, RK Spangler, V Cerdeira, M Ares… - bioRxiv, 2023 - biorxiv.org
Circadian rhythms are endogenous oscillations present in nearly all organisms from prokaryotes
to humans, allowing them to adapt to cyclical environments close to 24 hours. Circadian …

Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation

…, MM DeFelice, I Maayan, K Lane, RK Spangler… - Science, 2020 - science.org
… 3F) was ~23-fold higher than previous measurements and was closer to our new model k
cat value distribution. This supports others’ assertions that the effective k cat values for …

[HTML][HTML] Effects of grazer exclusion on carbon cycling in created freshwater wetlands

DM Spangler, AC Tyler, CK McCalley - Land, 2021 - mdpi.com
Wetland ecosystems play a significant role in the global carbon cycle, and yet are increasingly
threatened by human development and climate change. The continued loss of intact …

[PDF][PDF] An Integrated Assessment of Transportation to Healthy Food in Eastern Washtenaw County

…, J Grengs, J Billings, E Provonsha, K Spangler… - Ann Arbor …, 2012 - graham.umich.edu
1 Summary This research project investigated the degree to which residents of eastern
Washtenaw County experience difficulty in accessing healthy food, with a focus on finding …

[HTML][HTML] Evaluation of simulation models that estimate the effect of dietary strategies on nutritional intake: a systematic review

JA Grieger, BJ Johnson, TP Wycherley, RK Golley - The Journal of nutrition, 2017 - Elsevier
Background Dietary simulation modeling can predict dietary strategies that may improve
nutritional or health outcomes. Objectives The study aims were to undertake a systematic …

Depressive symptoms, bone loss, and fractures in postmenopausal women

L Spangler, D Scholes, RL Brunner, J Robbins… - Journal of general …, 2008 - Springer
Background Osteoporosis and depression may be associated through common physiologic
systems or risk factors. Objective To assess the associations between depressive symptoms (…

A de novo protein catalyzes the synthesis of semiconductor quantum dots

LC Spangler, Y Yao, G Cheng, N Yao… - Proceedings of the …, 2022 - National Acad Sciences
De novo proteins constructed from novel amino acid sequences are distinct from proteins that
evolved in nature. Construct K (ConK) is a binary-patterned de novo designed protein that …