Reconstitution of an intact clock reveals mechanisms of circadian timekeeping
INTRODUCTION Circadian clocks provide an internal representation of local time inside
cells and control the timing of gene expression in anticipation of sunrise and sunset. In …
cells and control the timing of gene expression in anticipation of sunrise and sunset. In …
Structural mimicry confers robustness in the cyanobacterial circadian clock
…, JG Palacios, C Sancar, DC Ernst, RK Spangler… - BioRxiv, 2020 - biorxiv.org
The histidine kinase SasA enhances robustness of circadian rhythms in the cyanobacterium
S. elongatus by temporally controlling expression of the core clock components, kaiB and …
S. elongatus by temporally controlling expression of the core clock components, kaiB and …
Potassium rhythms couple the circadian clock to the cell cycle
…, LL Hansen, E Grunewald, AD Beale, RK Spangler… - bioRxiv, 2024 - biorxiv.org
Circadian (~24 h) rhythms are a fundamental feature of life, and their disruption increases
the risk of infectious diseases, metabolic disorders, and cancer. Circadian rhythms couple to …
the risk of infectious diseases, metabolic disorders, and cancer. Circadian rhythms couple to …
Regulation of the circadian clock in C. elegans by clock gene homologs kin-20 and lin-42
ML Lamberti, RK Spangler, V Cerdeira, M Ares… - bioRxiv, 2023 - biorxiv.org
Circadian rhythms are endogenous oscillations present in nearly all organisms from prokaryotes
to humans, allowing them to adapt to cyclical environments close to 24 hours. Circadian …
to humans, allowing them to adapt to cyclical environments close to 24 hours. Circadian …
Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation
… 3F) was ~23-fold higher than previous measurements and was closer to our new model k
cat value distribution. This supports others’ assertions that the effective k cat values for …
cat value distribution. This supports others’ assertions that the effective k cat values for …
[HTML][HTML] Effects of grazer exclusion on carbon cycling in created freshwater wetlands
DM Spangler, AC Tyler, CK McCalley - Land, 2021 - mdpi.com
Wetland ecosystems play a significant role in the global carbon cycle, and yet are increasingly
threatened by human development and climate change. The continued loss of intact …
threatened by human development and climate change. The continued loss of intact …
[PDF][PDF] An Integrated Assessment of Transportation to Healthy Food in Eastern Washtenaw County
…, J Grengs, J Billings, E Provonsha, K Spangler… - Ann Arbor …, 2012 - graham.umich.edu
1 Summary This research project investigated the degree to which residents of eastern
Washtenaw County experience difficulty in accessing healthy food, with a focus on finding …
Washtenaw County experience difficulty in accessing healthy food, with a focus on finding …
[HTML][HTML] Evaluation of simulation models that estimate the effect of dietary strategies on nutritional intake: a systematic review
Background Dietary simulation modeling can predict dietary strategies that may improve
nutritional or health outcomes. Objectives The study aims were to undertake a systematic …
nutritional or health outcomes. Objectives The study aims were to undertake a systematic …
Depressive symptoms, bone loss, and fractures in postmenopausal women
L Spangler, D Scholes, RL Brunner, J Robbins… - Journal of general …, 2008 - Springer
Background Osteoporosis and depression may be associated through common physiologic
systems or risk factors. Objective To assess the associations between depressive symptoms (…
systems or risk factors. Objective To assess the associations between depressive symptoms (…
A de novo protein catalyzes the synthesis of semiconductor quantum dots
De novo proteins constructed from novel amino acid sequences are distinct from proteins that
evolved in nature. Construct K (ConK) is a binary-patterned de novo designed protein that …
evolved in nature. Construct K (ConK) is a binary-patterned de novo designed protein that …