Characterization of a RAD51C-silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistance
…, K Nesic, C Correia, TM Weiskittel, RL Kelly… - Nar …, 2021 - academic.oup.com
Acquired PARP inhibitor (PARPi) resistance in BRCA1- or BRCA2-mutant ovarian cancer
often results from secondary mutations that restore expression of functional protein. RAD51C …
often results from secondary mutations that restore expression of functional protein. RAD51C …
Repurposing ceritinib induces DNA damage and enhances PARP inhibitor responses in high-grade serous ovarian carcinoma
…, X Hou, TL Ekstrom, V Zanfagnin, AM Huehls, RL Kelly… - Cancer research, 2022 - AACR
The kinase inhibitor ceritinib synergizes with PARPi to induce tumor regression in ovarian
cancer models, suggesting that ceritinib combined with PARPi may be an effective strategy for …
cancer models, suggesting that ceritinib combined with PARPi may be an effective strategy for …
[HTML][HTML] Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitro and ex vivo
…, H Ding, AM Huehls, KS Flatten, RL Kelly… - Scientific reports, 2019 - nature.com
CPX-351 is a liposomally encapsulated 5:1 molar ratio of cytarabine and daunorubicin that
recently received regulatory approval for the treatment of therapy-related acute myeloid …
recently received regulatory approval for the treatment of therapy-related acute myeloid …
[PDF][PDF] Brazilin is a natural product inhibitor of the NLRP3 inflammasome
…, C Hoyle, L Fitzpatrick, EV Jones, E Corrie, RL Kelly… - Iscience, 2024 - cell.com
Excessive or aberrant NLRP3 inflammasome activation has been implicated in the
progression and initiation of many inflammatory conditions; however, currently no NLRP3 …
progression and initiation of many inflammatory conditions; however, currently no NLRP3 …
[HTML][HTML] Intra-S phase checkpoint kinase Chk1 dissociates replication proteins Treslin and TopBP1 through multiple mechanisms during replication stress
RL Kelly, AM Huehls, A Venkatachalam… - Journal of Biological …, 2022 - ASBMB
Replication stress impedes DNA polymerase progression causing activation of the ataxia
telangiectasia and Rad3-related signaling pathway, which promotes the intra-S phase …
telangiectasia and Rad3-related signaling pathway, which promotes the intra-S phase …
Quadriceps muscle strength and body mass index are associated with estimates of physical activity postheart transplantation
RL Kelly, JR Walsh, JD Paratz, ST Yerkovich… - …, 2019 - journals.lww.com
Background. Although exercise capacity improves postheart transplantation (HTx), it remains
unclear if the level of physical activity (PA) shows similar improvement. The purpose of this …
unclear if the level of physical activity (PA) shows similar improvement. The purpose of this …
ASSESSMENT OF MOTIVATIONAL INTERVIEWING PROFICIENCY IN CARDIAC REHABILITATION: Poster# S113
R Scales, E Hartlein, JK Manuel, RL Kelly… - Journal of …, 2008 - journals.lww.com
Purpose: This study was designed to assess MI proficiency during health education consultations
in an outpatient CR program. Design: Methods: Patients were given the Consultation …
in an outpatient CR program. Design: Methods: Patients were given the Consultation …
Characterization of a RAD51C-Silenced High Grade Serous Ovarian Cancer Model During PARP Inhibitor Resistance Development
…, K Nesic, C Correia, TM Weiskittel, RL Kelly… - bioRxiv, 2020 - biorxiv.org
Acquired PARP inhibitor (PARPi) resistance in BRCA1- or BRCA2-mutant ovarian cancer
often results from secondary mutations that restore expression of functional protein. RAD51C …
often results from secondary mutations that restore expression of functional protein. RAD51C …
Mosaic loss of the Y chromosome is associated with prostate cancer risk
RL Kelly, W Zhou, KM Barnao, CD Young, AK Hubbard… - Cancer Research, 2024 - AACR
Mosaic loss of the Y chromosome (mLOY), a type of clonal hematopoiesis, is the most
frequent chromosomal alteration observed in leukocytes of aging men. mLOY is a putative …
frequent chromosomal alteration observed in leukocytes of aging men. mLOY is a putative …
[PDF][PDF] Effect of CHK1 Inhibition on CPX-351 Cytotoxicity in vitroand ex vivo
ND Vincelette, H Ding, AM Huehls, KS Flatten, RL Kelly… - academia.edu
Results CPX-351 activates the replication checkpoint. In initial experiments, we examined
the effects of CPX-351 on cell cycle distribution of the AML cell line U937. To assure that …
the effects of CPX-351 on cell cycle distribution of the AML cell line U937. To assure that …