Sensing and responding to diverse extracellular signals: an updated analysis of the sensor kinases and response regulators of Streptomyces species
Streptomyces venezuelae is a Gram-positive, filamentous actinomycete with a complex
developmental life cycle. Genomic analysis revealed that S. venezuelae encodes a large …
developmental life cycle. Genomic analysis revealed that S. venezuelae encodes a large …
Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia
…, Z Tan, B Niu, KY Tsang, A Tai, WCW Chan, RLK Lo… - elife, 2018 - elifesciences.org
10.7554/eLife.37673.001 The integrated stress response (ISR) is activated by diverse forms
of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with …
of cellular stress, including endoplasmic reticulum (ER) stress, and is associated with …
COL10A1 nonsense and frame-shift mutations have a gain-of-function effect on the growth plate in human and mouse metaphyseal chondrodysplasia type Schmid
MSP Ho, KY Tsang, RLK Lo, M Susic… - Human molecular …, 2007 - academic.oup.com
Missense, nonsense and frame-shift mutations in the collagen X gene (COL10A1) result in
metaphyseal chondrodysplasia type Schmid (MCDS). Complete degradation of mutant …
metaphyseal chondrodysplasia type Schmid (MCDS). Complete degradation of mutant …
[PDF][PDF] Diversification of DNA-binding specificity by permissive and specificity-switching mutations in the ParB/Noc protein family
Specific interactions between proteins and DNA are essential to many biological processes.
Yet, it remains unclear how the diversification in DNA-binding specificity was brought about, …
Yet, it remains unclear how the diversification in DNA-binding specificity was brought about, …
Mechanistic insight into the repair of C8-linked pyrrolobenzodiazepine monomer-mediated DNA damage
AM Joseph, K Nahar, S Daw, MM Hasan, R Lo… - RSC Medicinal …, 2022 - pubs.rsc.org
Pyrrolobenzodiazepines (PBDs) are naturally occurring DNA binding compounds that
possess anti-tumor and anti-bacterial activity. Chemical modifications of PBDs can result in …
possess anti-tumor and anti-bacterial activity. Chemical modifications of PBDs can result in …
Co‐constructing family therapy in the Asian Chinese family diasporas of mainland China, Malaysia, Macau, Singapore and Taiwan
…, S Chan, J Teik Cheok Loy, S Sng, R Lo… - Journal of Family …, 2017 - Wiley Online Library
Asian Chinese families are experiencing constant changes. While commonly known cultural
themes such as ‘face’, ‘hierarchy’, ‘harmony’ and ‘filial piety’ are useful references and …
themes such as ‘face’, ‘hierarchy’, ‘harmony’ and ‘filial piety’ are useful references and …
Requirement for specific bacterial genome maintenance pathways in repair of C8-linked pyrrolobenzodiazepine (PBD) bi-aryl monomer-mediated DNA damage
AM Joseph, K Nahar, S Daw, MM Hasan, R Lo, TBK Le… - bioRxiv, 2022 - biorxiv.org
Pyrrolobenzodiazepines (PBDs) are naturally occurring DNA binding compounds that
possess anti-tumor and anti-bacterial activity. Chemical modifications of PBDs can result in …
possess anti-tumor and anti-bacterial activity. Chemical modifications of PBDs can result in …
[PDF][PDF] Characterization of a rationally engineered nitric oxide, nitrate and nitrite biosensor linked to a hybrid bacterial-mammalian promoter
…, J EdwardsHicks, R Gritton, L Harnisch, P Harvey, R Lo… - 2015 - academia.edu
Synthetic biology is principally concerned with the rational design and engineering of biological
systems that serve useful applied purposes. Biosensors are of particular interest to the …
systems that serve useful applied purposes. Biosensors are of particular interest to the …
Comparing the big five and indigenous dimensions of personality in Hong Kong Chinese
RCW Lo - 2004 - dspace.cityu.edu.hk
Objectives: The present study aimed to (i) identify personality dimensions that are salient to
the Hong Kong Chinese context on the basis of a taxonomy developed by Lai, Luk, and Wan (…
the Hong Kong Chinese context on the basis of a taxonomy developed by Lai, Luk, and Wan (…
[BOOK][B] Rebecca and Rowena
WM Thackeray, M Sweet - 2002 - editorialbelvedere.com
… Para mí, una de esas personas ha sido siempre mi querida Rebecca, hija de Isaac de York.
… Dándole a cada cual lo que le corresponde, siempre consideré que Rebecca tendría que …
… Dándole a cada cual lo que le corresponde, siempre consideré que Rebecca tendría que …