Human induced pluripotent stem cell (iPSC) lines are a powerful tool for studying
development and disease, but the considerable phenotypic variation between lines makes it …

Amyloid precursor protein (APP) and its cleavage fragment Amyloid-β (Aβ) have fundamental
roles in Alzheimer’s disease (AD). Genetic alterations that either increase the overall …

Spino-Cerebellar-Ataxia type 38 (SCA38) is caused by missense mutations in the very long
chain fatty acid elongase 5 gene, ELOVL5. The main clinical findings in this disease are …

Polymorphisms associated with BIN1 (bridging integrator 1) confer the second greatest risk
for developing late-onset Alzheimer’s disease. The biological consequences of this genetic …

Background Post-translational modifications of tau modify its interaction with binding partners
and cause tau mislocalisation and altered tau function in Alzheimer’s disease (AD). The …

Tauopathies including Alzheimer’s disease are characterized by tau protein modifications
that affect normal tau interactions and localization and lead to the development of …

Polymorphisms associated with BIN1 confer the second greatest risk for developing late
onset Alzheimer’s disease. The biological consequences of this genetic variation are not fully …

Assembly of the β-barrel outer membrane proteins (OMPs) is an essential cellular process
in Gram-negative bacteria and in the mitochondria and chloroplasts of eukaryotes—two …

Background: Familial Alzheimer's disease (fAD) is heterogeneous in terms of age at onset
and clinical presentation. A greater understanding of the pathogenicity of fAD variants and …

Floodwaters in New Orleans from Hurricanes Katrina and Rita were observed to contain high
levels of fecal indicator bacteria and microbial pathogens, generating concern about long-…