Rapid eye movement (REM) sleep is an important component of the natural sleep/wake
cycle, yet the mechanisms that regulate REM sleep remain incompletely understood. …

In the failing heart, the cardiac myocyte microtubule network is remodeled, which contributes
to cellular contractile failure and patient death. However, the origins of this deleterious …

10.7554/eLife.48117.001 The microtubule binding protein EB1 specifically targets the growing
ends of microtubules in cells, where EB1 facilitates the interactions of cellular proteins …

EB1 is a key cellular protein that delivers regulatory molecules throughout the cell via the tip-tracking
of growing microtubule plus-ends. Thus, it is important to understand the …

Although the function of protein kinase D1 (PKD) in cardiac cells has remained enigmatic,
recent work has shown that PKD phosphorylates the nuclear regulators HDAC5/7 (histone …

Microtubules are dynamic, filamentous polymers of α/β-tubulin heterodimers that form a
complex network throughout the cytoplasm. In cells, the microtubule cytoskeleton is subject to …

Estrogen (E2) is a well-known cardioprotective steroid hormone. Although heart has all the
machinery to biosynthesize estrogen from testosterone by cytochrome P450 aromatase, little …

Microtubules are cylindrical cytoskeletal polymers composed of α/β-tubulin heterodimers
that make up an ordered tubulin lattice. In cells, microtubules form a network that is a key …

EB1 is a protein that tracks growing microtubule plus-ends, manifesting as a comet-like structure
slightly behind the microtubule tip (‘EB1 tip tracking’). EB1 localizes proteins to growing …

Microtubules are cytoskeletal polymers that play essential roles during multiple cellular
processes. Dynamic nature of these polymers allows them to remodel the microtubule network …