Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to
sarcomere insufficiency. However, it remains mechanistically unclear how these mutations …

Robust control of human induced pluripotent stem cell (hIPSC) differentiation is essential to
realize its patient-tailored therapeutic potential. Here, we demonstrate a novel application of …

Background: Tissue fibrosis is a major healthcare burden that affects various organs in the
body for which no effective treatments exist. An underlying, emerging theme across organs …

Background To maximize the translational utility of human induced pluripotent stem cells (iPSCs),
the ability to precisely modulate the differentiation of iPSCs to target phenotypes is …

Electrospun scaffolds with varied stiffness promote distinct colony morphology of human
induced pluripotent stem cells, which affects their subsequent differentiation. On soft scaffolds, …

The structural and functional maturation of human induced pluripotent stem cell-derived
cardiomyocytes (hiPSC-CMs) is essential for pharmaceutical testing, disease modeling, and …

COVID-19 emerged as a worldwide pandemic in early 2020, and while the rapid
development of safe and efficacious vaccines stands as an extraordinary achievement, the …

Nearly half of American adults suffer from gum disease, including mild inflammation of gingival
tissue, known as gingivitis. Currently, advances in therapeutic treatments are hampered …

COVID-19 emerged as a worldwide pandemic early in 2020, and at this writing has caused
over 170 million cases and 3.7 million deaths worldwide, and almost 600,000 deaths in the …

Despite the relatively common observation of therapeutic efficacy in discovery screens with
immortalized cell lines, the vast majority of drug candidates do not reach clinical development…