Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis
RR Riley, S Duensing, T Brake, K Munger, PF Lambert… - Cancer research, 2003 - AACR
Human cervix cancer is caused by high-risk human papillomaviruses encoding E6 and E7
oncoproteins, each of which alter function of distinct targets regulating the cell cycle, apoptosis…
oncoproteins, each of which alter function of distinct targets regulating the cell cycle, apoptosis…
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
…, E Silva, K Vitangcol, KO Shin, YM Lee, R Riley… - Nature …, 2020 - nature.com
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …
[PDF][PDF] Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
…, C Kuehnemann, B Kaplowitz, D Bhaumik, RR Riley… - Cell metabolism, 2020 - cell.com
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …
Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis
DA Elson, RR Riley, A Lacey, G Thordarson… - Cancer research, 2000 - AACR
Regions where one type of epithelium replaces another (metaplasia) have a predilection for
cancer formation. Environmental factors are closely linked to metaplastic carcinogenesis. In …
cancer formation. Environmental factors are closely linked to metaplastic carcinogenesis. In …
Immune modulation by MANF promotes tissue repair and regenerative success in the retina
INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …
treatment of a range of age-related degenerative diseases but are limited by unfavorable …
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors
JMA Oliveira, S Chen, S Almeida, R Riley… - Journal of …, 2006 - Soc Neuroscience
Evidence suggests that neuronal dysfunction in Huntington's disease (HD) striatum involves
deficits in mitochondrial function and in Ca 2+ handling. However, the relationship between …
deficits in mitochondrial function and in Ca 2+ handling. However, the relationship between …
MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage
Ageing is accompanied by altered intercellular communication, deregulated metabolic
function, and inflammation. Interventions that restore a youthful state delay or reverse these …
function, and inflammation. Interventions that restore a youthful state delay or reverse these …
[PDF][PDF] mTORC1 activation during repeated regeneration impairs somatic stem cell maintenance
The balance between self-renewal and differentiation ensures long-term maintenance of
stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during …
stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during …
PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila
10.7554/eLife.26952.001 The mitochondrial unfolded protein response (UPR mt ) has been
associated with long lifespan across metazoans. In Caenorhabditis elegans, mild …
associated with long lifespan across metazoans. In Caenorhabditis elegans, mild …
[HTML][HTML] Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model
SR Danielson, JM Held, M Oo, R Riley… - Journal of biological …, 2011 - ASBMB
Differential cysteine oxidation within mitochondrial Complex I has been quantified in an in
vivo oxidative stress model of Parkinson disease. We developed a strategy that incorporates …
vivo oxidative stress model of Parkinson disease. We developed a strategy that incorporates …