Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis

RR Riley, S Duensing, T Brake, K Munger, PF Lambert… - Cancer research, 2003 - AACR
Human cervix cancer is caused by high-risk human papillomaviruses encoding E6 and E7
oncoproteins, each of which alter function of distinct targets regulating the cell cycle, apoptosis…

Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages

…, E Silva, K Vitangcol, KO Shin, YM Lee, R Riley… - Nature …, 2020 - nature.com
Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and
its associated diseases. However, the mechanism for this decline is unclear. Here, we show …

[PDF][PDF] Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

…, C Kuehnemann, B Kaplowitz, D Bhaumik, RR Riley… - Cell metabolism, 2020 - cell.com
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …

Sensitivity of the cervical transformation zone to estrogen-induced squamous carcinogenesis

DA Elson, RR Riley, A Lacey, G Thordarson… - Cancer research, 2000 - AACR
Regions where one type of epithelium replaces another (metaplasia) have a predilection for
cancer formation. Environmental factors are closely linked to metaplastic carcinogenesis. In …

Immune modulation by MANF promotes tissue repair and regenerative success in the retina

J Neves, J Zhu, P Sousa-Victor, M Konjikusic, R Riley… - Science, 2016 - science.org
INTRODUCTION Regenerative therapies based on cell replacement hold promise for the
treatment of a range of age-related degenerative diseases but are limited by unfavorable …

Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors

JMA Oliveira, S Chen, S Almeida, R Riley… - Journal of …, 2006 - Soc Neuroscience
Evidence suggests that neuronal dysfunction in Huntington's disease (HD) striatum involves
deficits in mitochondrial function and in Ca 2+ handling. However, the relationship between …

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage

…, W Cedron-Craft, PB Ventura, CY Liao, RR Riley… - Nature …, 2019 - nature.com
Ageing is accompanied by altered intercellular communication, deregulated metabolic
function, and inflammation. Interventions that restore a youthful state delay or reverse these …

[PDF][PDF] mTORC1 activation during repeated regeneration impairs somatic stem cell maintenance

S Haller, S Kapuria, RR Riley, MN O'Leary… - Cell stem cell, 2017 - cell.com
The balance between self-renewal and differentiation ensures long-term maintenance of
stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during …

PGAM5 promotes lasting FoxO activation after developmental mitochondrial stress and extends lifespan in Drosophila

M Borch Jensen, Y Qi, R Riley, L Rabkina, H Jasper - Elife, 2017 - elifesciences.org
10.7554/eLife.26952.001 The mitochondrial unfolded protein response (UPR mt ) has been
associated with long lifespan across metazoans. In Caenorhabditis elegans, mild …

[HTML][HTML] Quantitative mapping of reversible mitochondrial Complex I cysteine oxidation in a Parkinson disease mouse model

SR Danielson, JM Held, M Oo, R Riley… - Journal of biological …, 2011 - ASBMB
Differential cysteine oxidation within mitochondrial Complex I has been quantified in an in
vivo oxidative stress model of Parkinson disease. We developed a strategy that incorporates …