A primary goal of molecular physiology is to understand how conformational changes of
proteins affect the function of cells, tissues, and organisms. Here, we describe an imaging …

Ion channels are polymorphic membrane proteins whose high-resolution structures offer
images of individual conformations, giving us starting points for identifying the complex and …

Kv2 voltage-gated potassium channels are modulated by amphoterin-induced gene and
open reading frame (AMIGO) neuronal adhesion proteins. Here, we identify steps in the …

A selective inhibitor is a drug that inhibits the function of one type of protein more than others.
This precise block of function can reveal the physiological role of the targeted endogenous …

A primary goal of molecular physiology is to understand the coupling between protein
conformational change and systemic function. To see the conformational changes of a voltage-…

Kv2 voltage-gated potassium channels are modulated by AMIGO neuronal adhesion proteins.
Here, we identify steps in the conductance activation pathway of Kv2.1 channels that are …

Ion channels are polymorphic membrane proteins whose high-resolution structures offer
images of individual conformations, giving us starting points for identifying the complex and …

The relationship between membrane potential and the conductance of Kv2-type voltage gated
K+ channels is modulated by cells. To begin studies into the mechanistic underpinnings …

A primary goal of molecular physiology is to understand how proteins change their conformation.
Here, we describe a spectral imaging method for measuring conformational changes of …

A primary goal of molecular physiology is to understand the coupling between protein
conformational change and systemic function. To see the conformational changes of a …