Objective To compare the efficacy, safety, and cost effectiveness of direct acting oral
anticoagulants (DOACs) for patients with atrial fibrillation. Design Systematic review, network meta-…

Aims To investigate the causal role of high-density lipoprotein cholesterol (HDL-C) and
triglycerides in coronary heart disease (CHD) using multiple instrumental variables for Mendelian …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

ACE Inhibitors or ARBs and Incident Influenza Certain influenza strains and SARS-CoV-2
gain access to cells by means of the ACE2 receptor. In this database study in the United …

Background Non-uniform reporting of relevant relationships and metrics hampers critical
appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later …

Mendelian randomization (MR) studies typically assess the pathogenic relevance of
environmental exposures or disease biomarkers, using genetic variants that instrument these …

BACKGROUND: Warfarin is effective for stroke prevention in atrial fibrillation (AF), but
anticoagulation is underused in clinical care. The risk of venous thromboembolic disease during …

BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia that increases the risk
of thromboembolic events. Anticoagulation therapy to prevent AF-related stroke has been …

Objective To monitor hospital activity for presentation, diagnosis and treatment of
cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects. Methods …

Background Increased circulating plasma urate concentration is associated with an increased
risk of coronary heart disease, but the extent of any causative effect of urate on risk of …