Dynamic genetic regulation of gene expression during cellular differentiation

BJ Strober, R Elorbany, K Rhodes, N Krishnan… - Science, 2019 - science.org
Genetic regulation of gene expression is dynamic, as transcription can change during cell
differentiation and across cell types. We mapped expression quantitative trait loci (eQTLs) …

[HTML][HTML] Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation

R Elorbany, JM Popp, K Rhodes, BJ Strober… - PLoS …, 2022 - journals.plos.org
Dynamic and temporally specific gene regulatory changes may underlie unexplained
genetic associations with complex disease. During a dynamic process such as cellular …

[HTML][HTML] PPARγ-Independent side effects of thiazolidinediones on mitochondrial redox state in rat isolated hearts

ML Riess, R Elorbany, D Weihrauch, DF Stowe… - Cells, 2020 - mdpi.com
The effect of anti-diabetic thiazolidinediones (TZDs) on contributing to heart failure and cardiac
ischemia/reperfusion (IR) injury is controversial. In this study we investigated the effect of …

[HTML][HTML] Systematic comparison of high-throughput single-cell and single-nucleus transcriptomes during cardiomyocyte differentiation

…, H Eckart, S Lozano, B Xie, E Gauchat, R Elorbany… - Scientific reports, 2020 - nature.com
A comprehensive reference map of all cell types in the human body is necessary for improving
our understanding of fundamental biological processes and in diagnosing and treating …

Investigating the Dynamics of Gene Regulation During Cardiomyocyte Differentiation Using Bulk and Single Cell RNA Sequencing

R Elorbany - 2020 - search.proquest.com
Genetic variants that alter gene regulation play a crucial role in the genetics of human
development and disease. Although genome-wide association studies have found thousands of …

Acute Administration of PPARγ Agonist Rosiglitazone in Isolated Hearts Differentially Aggravates Cardiac Ischemia Reperfusion Injury in a Consomic Rat Model

Q Cheng, R Elorbany, D Stowe, A Camara… - 2013 - Wiley Online Library
The effect of peroxisome proliferator‐activated receptor‐gamma (PPARγ) agonist
rosiglitazone (RGZ), a thiazolidinedione (TZL), on cardiac ischemia/reperfusion (IR) injury is …

Modeling the impact of genetic variation on gene expression

BJ Strober - 2021 - jscholarship.library.jhu.edu
… Most notably, I would like to thank Yoav Gilad, Katie Rhodes and Reem Elorbany at University
of Chicago for a fantastic collaboration while we studied dynamic genetic effects during …

[HTML][HTML] Interrogating the 3D Structure of Primate Genomes

IE Eres - 2020 - search.proquest.com
A primary goal in human genetics is to understand how genetic variation affects phenotypic
variation observed between different individuals. Elucidating these connections is crucial to …

The Phosphorylation-Dependent Regulation of the RNA N6-Methyladenosine Methyltransferase Complex

AC Zhu - 2021 - search.proquest.com
… I thank Mat Schnorenberg and Michael Clark for their mentorship on grant applications,
and Reem Elorbany for her mentorship and support. I want to thank my MSTP cohort for …

Investigating the Dynamic Regulation of Gene Expression During Cellular Differentiation

KL Rhodes - 2021 - search.proquest.com
… No one has shaped my grad school experience more than Reem Elorbany—my lab twin,
the other head of my doduo, the brain to my pinky. We worked side by side from our very first …