Technology utilizing human induced pluripotent stem cells (iPS cells) has enormous potential
to provide improved cellular models of human disease. However, variable genetic and …

Glycopeptide antibiotics have been a key weapon in the fight against bacterial infections for
over half a century, with the progenitors, vancomycin (1) and teicoplanin (2), still used …

Activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
drives release of the proinflammatory cytokines interleukin (IL)-1β and IL-18 and induces …

Ischemia-reperfusion injury (IRI) is a common occurrence following myocardial infarction,
transplantation, stroke, and trauma that can lead to multiple organ failure, which remains the …

ConoServer is a new database dedicated to conopeptides, a large family of peptides found
in the venom of marine snails of the genus Conus. These peptides have an exceptional …

Covering: up to the end of 2008 Venomous marine cone snails harbour a variety of small
disulfide-rich peptides called conotoxins, which target a broad range of ion channels, …

The complement cascade is comprised of a highly sophisticated network of innate immune
proteins that are activated in response to invading pathogens or tissue injury. The …

Vc1.1 is a disulfide-rich peptide inhibitor of nicotinic acetylcholine receptors that has stimulated
considerable interest in these receptors as potential therapeutic targets for the treatment …

The complement system is a major component of our innate immune system, in which the
complement proteins C5a and C5a‐des Arg bind to two G‐protein‐coupled receptors: namely, …

Receptors for C5a have an important role in innate immunity and inflammation where their
expression and activation is tightly regulated. There are two known receptors for C5a: the C5a …