Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Background and Purpose: Stroke is the leading cause of death and long-term disability
worldwide. Previous genome-wide association studies identified 51 loci associated with stroke (…

In this study, the asymptotic distributions of the likelihood ratio test (LRT), the restricted
likelihood ratio test (RLRT), the F and the sequence kernel association test (SKAT) statistics for …

The effects of assortative mating (AM) on estimates from genetic studies has been receiving
increasing attention in recent years. We extend existing AM theory to more general models …

Inflammation biomarkers can provide valuable insight into the role of inflammatory processes
in many diseases and conditions. Sequencing based analyses of such biomarkers can …

Malignant progression of normal tissue is typically driven by complex networks of somatic
changes, including genetic mutations, copy number aberrations, epigenetic changes, and …

Prenatal socioeconomic disadvantage (SD) has been linked to DNA methylation (DNAm) in
adulthood, but whether such epigenetic alterations are present at birth remains unclear. We …

Familial relatedness (FR) and population structure (PS) are two major sources for genetic
correlation. In the human population, both FR and PS can further break down into additive and …

Background Antibiotics (ABX) are often prescribed for acute bronchitis (AB). Reducing
inappropriate ambulatory ABX use is critical to combat ABX resistance and reduce ABX-related …