The database of known protein three‐dimensional structures can be significantly increased
by the use of sequence homology, based on the following observations. (1) The database of …

The Protein Data Bank currently contains about 600 data sets of three‐dimensional protein
coordinates determined by X‐ray crystallography or NMR. There is considerable redundancy …

The maintenance of protein function and structure constrains the evolution of amino acid
sequences. This fact can be exploited to interpret correlated mutations observed in a sequence …

Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

By the middle of 1993, >30 000 protein sequences had been listed. For 1000 of these, the
three-dimensional (tertiary) structure has been experimentally solved. Another 7000 can be …

Understanding complex systems often requires a bottom-up analysis towards a systems
biology approach. The need to investigate a system, not only as individual components but as a …

The Protein Data Bank (PDB) is the world-wide repository of macromolecular structure
information. We present a series of databases that run parallel to the PDB. Each database holds …

The molecular basis of drug action is often not well understood. This is partly because the
very abundant and diverse information generated in the past decades on drugs is hidden in …

PredictProtein is a meta-service for sequence analysis that has been predicting structural
and functional features of proteins since 1992. Queried with a protein sequence it returns: …

High-throughput studies of biological systems are rapidly accumulating a wealth of 'omics'-scale
data. Visualization is a key aspect of both the analysis and understanding of these data, …