Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present
no antifibrotic therapies exist 1 , 2 – 3 . The origin, functional heterogeneity and regulation of …

Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis
by causing deregulation of proto-oncogenes via relocation of cryptic regulatory DNA …

Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether
this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney …

Myocardial infarction is a leading cause of death worldwide 1 . Although advances have
been made in acute treatment, an incomplete understanding of remodelling processes has …

Mesenchymal niche cells may drive tissue failure and malignant transformation in the
hematopoietic system, but the underlying molecular mechanisms and relevance to human disease …

Progression and persistence of malignancies are influenced by the local tumor
microenvironment, and future eradication of currently incurable tumors will, in part, hinge on our …

Bone marrow fibrosis (BMF) develops in various hematological and non-hematological
conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted …

Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic
options. The mechanisms underlying LMS development, including clinically actionable genetic …

Adult kidney organoids have been described as strictly tubular epithelia and termed
tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they …

Severe congenital neutropenia (CN) is a preleukemic bone marrow failure syndrome with a
20% risk of evolving into leukemia or myelodysplastic syndrome (MDS). Patterns of …