Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations
determining the clinicobiological behaviour are not fully understood. Here we describe a …

Chronic lymphocytic leukemia (CLL) is a frequent hematological neoplasm in which
underlying epigenetic alterations are only partially understood. Here, we analyze the reference …

We report a systematic analysis of the DNA methylation variability in 1,595 samples of normal
cell subpopulations and 14 tumor subtypes spanning the entire human B-cell lineage. …

Ever since the discovery of DNA methylation at cytosine residues, the role of this so called
fifth base has been extensively studied and debated. Until recently, the majority of DNA …

Severe congenital neutropenia (SCN) is a BM failure syndrome with a high risk of progression
to acute myeloid leukemia (AML). The underlying genetic changes involved in SCN …

We analyzed the DNA methylome of ten subpopulations spanning the entire B cell differentiation
program by whole-genome bisulfite sequencing and high-density microarrays. We …

Granulocyte colony-stimulating factor (G-CSF) has been used in the clinic for more than 2
decades to treat congenital and acquired neutropenias and to reduce febrile neutropenia …

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by
whole-genome bisulfite sequencing and high-density arrays, we observed a highly …

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL)
in comparison with cell subpopulations spanning the entire B cell lineage. We …

B cells have the unique property to somatically alter their immunoglobulin (IG) genes by V(D)J
recombination, somatic hypermutation (SHM) and class-switch recombination (CSR). …