The prevalence of type 2 diabetes (T2D) is rapidly increasing, and effective strategies to
manage and prevent this disease are urgently needed. Resistance training (RT) promotes …

The sites and rates of mitochondrial production of superoxide and H 2 O 2 in vivo are not yet
defined. At least 10 different mitochondrial sites can generate these species. Each site has …

Several flavin-dependent enzymes of the mitochondrial matrix utilize NAD + or NADH at
about the same operating redox potential as the NADH/NAD + pool and comprise the NADH/…

Background The rate at which cells acidify the extracellular medium is frequently used to
report glycolytic rate, with the implicit assumption that conversion of uncharged glucose or …

The presence of bacteria in the midgut of mosquitoes antagonizes infectious agents, such
as Dengue and Plasmodium, acting as a negative factor in the vectorial competence of the …

Mitochondrial electron transport drives ATP synthesis but also generates reactive oxygen
species, which are both cellular signals and damaging oxidants. Superoxide production by …

Using high-throughput screening we identified small molecules that suppress superoxide
and/or H 2 O 2 production during reverse electron transport through mitochondrial respiratory …

Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or
cold exposure, and they are thus an important cell type for the maintenance of proper …

Despite ongoing efforts, the current treatment for Chagas disease is still unsatisfactory, mainly
because of the severe side effects and variable efficacy of the available nitroheterocycles. …

Mitochondrial reactive oxygen species (ROS) are widely implicated in physiological and
pathological pathways. We propose that it is critical to understand the specific sites of …