Human Immunodeficiency Viruses (HIV-1 and HIV-2) rely upon host-encoded proteins to
facilitate their replication. Here, we combined genome-wide siRNA analyses with interrogation …

The HIV-1 accessory protein Vif (virion infectivity factor) is required for the production of
infectious virions by CD4 + lymphocytes. Vif facilitates particle infectivity by blocking the inhibitory …

Influenza A virus is an RNA virus that encodes up to 11 proteins and this small coding capacity
demands that the virus use the host cellular machinery for many aspects of its life cycle 1 . …

Several systems-level datasets designed to dissect host-pathogen interactions during influenza
A infection have been reported. However, apparent discordance among these data has …

HIV-1 deleted for the vif accessory gene encapsidates the cellular cytidine deaminase
APOBEC3G. Upon infection, the encapsidated APOBEC3G induces G→A mutations in the viral …

Unlike activated CD4 + T cells, resting CD4 + T cells are highly resistant to productive HIV-1
infection 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 . Early after HIV-1 entry, a major block limits reverse …

We have analyzed host cell genes linked to HIV replication that were identified in nine
genome-wide studies, including three independent siRNA screens. Overlaps among the siRNA …

We describe a statistical analysis methodology designed to minimize the impact of off-target
activities upon large-scale RNA interference (RNAi) screens in mammalian cells. …

In the human genome the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC)3
gene has expanded into a tandem array of genes termed APOBEC3A-G. Two …

The HIV-1 viral accessory protein Vif prevents the encapsidation of the antiviral cellular cytidine
deaminases APOBEC3F and APOBEC3G by inducing their proteasomal degradation. In …