Max is the central component of the Myc/Max/Mad network of transcription factors that regulate
growth, differentiation and apoptosis. Whereas the Myc and Mad genes and proteins are …

The WHO declared the COVID-19 outbreak a public health emergency of international
concern. The causative agent of this acute respiratory disease is a newly emerged coronavirus, …

Discovery and optimization of potency and selectivity of a non-Zn-chelating MMP-13
inhibitor with the aid of protein co-crystal structural information is reported. This inhibitor was …

The over-expression and aggregation of α-synuclein (αSyn) are linked to the onset and
pathology of Parkinson’s disease. Native monomeric αSyn exists in an intrinsically disordered …

Surface plasmon resonance imaging, a low affinity screening method, allows the highly
parallel detection of small molecules binding to a target protein. The screening of a fragment …

The goal of this study was to explore the applicability of surface plasmon resonance (SPR)-based
fragment screening to identify compounds that bind to factor VIIa (FVIIa). Based on …

Libraries of small molecules were searched for Fc-fragment selective binders to a recombinant
human antibody (“MDJ8″, IgG 1 -subtype, κ-light chain) via SPR-based screening of …

Surface plasmon resonance (SPR) is known to be a versatile tool for the study of biomolecular
interactions that can generate affinity data in a highly sensitive and label-free detection …

(57) ABSTRACT The invention provides novel, substituted 3-arylamino pyridine compounds
(I) pharmaceutically acceptable salts, sol-vates and prodrug compounds thereof, wherein W, …

▪ Largest library for the identification of prognostic RA peptides▪ Strong and differential
autoantibody response in early-stage autoimmune rheumatic diseases▪ Novel epitopes in …