Several strains that grow on medium-chain-length alkanes and catalyze interesting hydroxylation
and epoxidation reactions do not possess integral membrane nonheme iron alkane …

A number of oxygenated monoterpenes present at low concentrations in plant oils have
anticarcinogenic properties. One of the most promising compounds in this respect is (−)-perillyl …

The application and integration of molecular profiling technologies create novel opportunities
for personalized medicine. Here, we introduce the Tumor Profiler Study, an observational …

Chromosome segregation in metazoans requires the alignment of sister kinetochores on
the metaphase plate. During chromosome alignment, bioriented kinetochores move …

High‐content imaging using automated microscopy and computer vision allows multivariate
profiling of single‐cell phenotypes. Here, we present methods for the application of the …

At the onset of mitosis, cells need to break down their nuclear envelope, form a bipolar
spindle and attach the chromosomes to microtubules via kinetochores. Previous studies have …

Coordination of cell cycle events in space and time is crucial to achieve a successful cell
division. Here, we demonstrate that UBXN-2, a substrate adaptor of the AAA ATPase Cdc48/p97…

Brain organoids enable the mechanistic study of human brain development, and provide
opportunities to explore self-organization in unconstrained developmental systems. Here, we …

The formation and orientation of the mitotic spindle is a critical feature of mitosis. The
morphology of the cell and the spatial distribution and composition of the cells' adhesive …

Caspases are key components of apoptotic pathways. Regulation of caspases occurs at
several levels, including transcription, proteolytic processing, inhibition of enzymatic function, …