With the widespread deployment and use of wireless data communications in the mobile
computing domain the need for middleware that interconnects the components that comprise a …

Event-based middleware is currently being applied for application component integration in
a range of application domains. As a result, a variety of event services has been proposed to …

Recent studies on the enzymatic degradation of synthetic polyesters have shown the
potential of polyester hydrolases from thermophilic actinomycetes for modifying or degrading …

Suramin is a symmetric polyanionic naphthylurea originally used for the treatment of
trypanosomiasis and onchocerciasis. Suramin and diverse analogues exhibit a broad range of …

NAD + -dependent histone deacetylases (sirtuins) are enzymes that cleave acetyl groups
from lysines in histones and other proteins. Potent selective sirtuin inhibitors are interesting …

NAD + -dependent histone deacetylases, sirtuins, cleave acetyl groups from lysines of
histones and other proteins to regulate their activity. Identification of potent selective inhibitors …

Despite recent breakthroughs in the structural characterization of G‐protein‐coupled receptors
(GPCRs), there is only sparse data on how GPCRs recognize larger peptide ligands. …

Current virtual screening tools are fast, but reliable scoring is elusive. Here, we present the ‘SQM/COSMO
filter’, a novel scoring function featuring a quantitative semiempirical quantum …

Middleware supporting event-based communication is widely recognized as being well
suited to mobile applications since it naturally accommodates a dynamically changing …

Metabolomics is the modern term for the field of small molecule research in biology and
biochemistry. Currently, metabolomics is undergoing a transition where the classic analytical …