User profiles for Renhua Wu
 | Renhua WuThe Second Affiliated Hospital of Shantou University Medical College Verified email at stu.edu.cn Cited by 3439 |
A global reference for human genetic variation
…, Y Lu, X Ma, M Tang, B Wang, G Wang, H Wu, R Wu… - Nature, 2015 - cdr.lib.unc.edu
The 1000 Genomes Project set out to provide a comprehensive description of common human
genetic variation by applying whole-genome sequencing to a diverse set of individuals …
genetic variation by applying whole-genome sequencing to a diverse set of individuals …
Sequencing of 50 human exomes reveals adaptation to high altitude
Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We
sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human …
sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human …
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder
Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we
sequenced the exomes of nine individuals with TCC and screened all the somatically mutated …
sequenced the exomes of nine individuals with TCC and screened all the somatically mutated …
[HTML][HTML] Single-cell exome sequencing reveals single-nucleotide mutation characteristics of a kidney tumor
Clear cell renal cell carcinoma (ccRCC) is the most common kidney cancer and has very few
mutations that are shared between different patients. To better understand the intratumoral …
mutations that are shared between different patients. To better understand the intratumoral …
[HTML][HTML] Single-cell exome sequencing and monoclonal evolution of a JAK2-negative myeloproliferative neoplasm
Tumor heterogeneity presents a challenge for inferring clonal evolution and driver gene
identification. Here, we describe a method for analyzing the cancer genome at a single-cell …
identification. Here, we describe a method for analyzing the cancer genome at a single-cell …
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
…, Q Li, J Liu, X Liu, T Sparsø, M Tang, H Wu, R Wu… - Nature …, 2010 - nature.com
Targeted capture combined with massively parallel exome sequencing is a promising approach
to identify genetic variants implicated in human traits. We report exome sequencing of …
to identify genetic variants implicated in human traits. We report exome sequencing of …
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and
performed a screen of ∼1,100 genes in 88 additional ccRCCs, from which we discovered 12 …
performed a screen of ∼1,100 genes in 88 additional ccRCCs, from which we discovered 12 …
A large-scale screen for coding variants predisposing to psoriasis
…, H Cheng, Y Qiu, G Chen, J Mei, F Zhou, R Wu… - Nature …, 2014 - nature.com
To explore the contribution of functional coding variants to psoriasis, we analyzed nonsynonymous
single-nucleotide variants (SNVs) across the genome by exome sequencing in 781 …
single-nucleotide variants (SNVs) across the genome by exome sequencing in 781 …
[HTML][HTML] A diagnostic model for coronavirus disease 2019 (COVID-19) based on radiological semantic and clinical features: a multi-center study
Objectives Rapid and accurate diagnosis of coronavirus disease 2019 (COVID-19) is critical
during the epidemic. We aim to identify differences in CT imaging and clinical …
during the epidemic. We aim to identify differences in CT imaging and clinical …
Exome sequencing identifies NMNAT1 mutations as a cause of Leber congenital amaurosis
…, J Wang, Y Chen, Q Fu, J Zhong, Y Chen, X Yi, R Wu… - Nature …, 2012 - nature.com
Leber congenital amaurosis (LCA) is an autosomal recessive retinal dystrophy that manifests
with genetic heterogeneity. We sequenced the exome of an individual with LCA and …
with genetic heterogeneity. We sequenced the exome of an individual with LCA and …