User profiles for Reuben Shaw
 | Reuben ShawThe Salk Institute of Biological Studies Verified email at salk.edu Cited by 60898 |
Resveratrol improves health and survival of mice on a high-calorie diet
Resveratrol (3,5,4′-trihydroxystilbene) extends the lifespan of diverse species including
Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these …
Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these …
[PDF][PDF] AMPK phosphorylation of raptor mediates a metabolic checkpoint
AMPK is a highly conserved sensor of cellular energy status that is activated under conditions
of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and …
of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and …
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
MM Mihaylova, RJ Shaw - Nature cell biology, 2011 - nature.com
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated
protein kinase (AMPK), which is activated when intracellular ATP production …
protein kinase (AMPK), which is activated when intracellular ATP production …
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
Adenosine monophosphate–activated protein kinase (AMPK) is a conserved sensor of
intracellular energy activated in response to low nutrient availability and environmental stress. In …
intracellular energy activated in response to low nutrient availability and environmental stress. In …
Ras, PI (3) K and mTOR signalling controls tumour cell growth
RJ Shaw, LC Cantley - Nature, 2006 - nature.com
All eukaryotic cells coordinate cell growth with the availability of nutrients in their environment.
The mTOR protein kinase has emerged as a critical growth-control node, receiving …
The mTOR protein kinase has emerged as a critical growth-control node, receiving …
AMPK: guardian of metabolism and mitochondrial homeostasis
Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase,
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–…
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–…
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw, M Kosmatka, N Bardeesy… - Proceedings of the …, 2004 - National Acad Sciences
AMP-activated protein kinase (AMPK) is a highly conserved sensor of cellular energy status
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …
found in all eukaryotic cells. AMPK is activated by stimuli that increase the cellular AMP/ATP …
The LKB1–AMPK pathway: metabolism and growth control in tumour suppression
DB Shackelford, RJ Shaw - Nature Reviews Cancer, 2009 - nature.com
In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …
[PDF][PDF] AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
AMPK has emerged as a critical mechanism for salutary effects of polyphenols on lipid metabolic
disorders in type 1 and type 2 diabetes. Here we demonstrate that AMPK interacts with …
disorders in type 1 and type 2 diabetes. Here we demonstrate that AMPK interacts with …