Induction of antigen-specific CD8 + T cells offers the prospect of immunization against many
infectious diseases, but no subunit vaccine has induced CD8 + T cells that correlate with …

A major gap in the Plasmodium vivax elimination toolkit is the identification of individuals
carrying clinically silent and undetectable liver-stage parasites, called hypnozoites. This study …

Background Controlled human malaria infection (CHMI) studies have become a routine tool
to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have …

Background Primaquine is used to eliminate Plasmodium vivax hypnozoites, but its optimal
dosing regimen remains unclear. We undertook a systematic review and individual patient …

Plasmodium vivax is the most geographically widespread of the malaria parasites causing
human disease, yet it is comparatively understudied compared with Plasmodium falciparum. …

Plasmodium vivax remains an important cause of malaria in South America and the Asia-Pacific.
Naturally acquired antibody responses against multiple P. vivax proteins have been …

The development of an efficacious Plasmodium falciparum malaria vaccine remains a top
priority for global health. Vaccination with irradiated sporozoites is able to provide complete …

Plasmodium vivax is now the dominant Plasmodium species causing malaria in Thailand,
yet little is known about naturally acquired immune responses to this parasite in this low-…

Background In malaria endemic populations, complex patterns of Plasmodium vivax and
Plasmodium falciparum blood-stage infection dynamics may be observed. Genotyping samples …

The orthodox role of the invariant chain (CD74; Ii) is in antigen presentation to CD4 + T cells,
but enhanced CD8 + T cells responses have been reported after vaccination with vectored …