[HTML][HTML] Relationship between RPE and choriocapillaris in age-related macular degeneration
purpose. The purpose of this study was to examine the relationships between choriocapillaris
(CC) and retinal pigment epithelial changes in age-related macular degeneration (AMD). …
(CC) and retinal pigment epithelial changes in age-related macular degeneration (AMD). …
[HTML][HTML] Photoreceptor outer segment-like structures in long-term 3D retinas from human pluripotent stem cells
The retinal degenerative diseases, which together constitute a leading cause of hereditary
blindness worldwide, are largely untreatable. Development of reliable methods to culture …
blindness worldwide, are largely untreatable. Development of reliable methods to culture …
Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD
…, O Chowdhury, M Nemani, V Maddipatla, R Grebe… - Autophagy, 2023 - Taylor & Francis
In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, …
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, …
Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling
M Valapala, C Wilson, S Hose, IA Bhutto, R Grebe… - Autophagy, 2014 - Taylor & Francis
In phagocytic cells, including the retinal pigment epithelium (RPE), acidic compartments of
the endolysosomal system are regulators of both phagocytosis and autophagy, thereby …
the endolysosomal system are regulators of both phagocytosis and autophagy, thereby …
Choroidal blood flow in diabetic retinopathy
ME Langham, R Grebe, S Hopkins, S Marcus… - Experimental eye …, 1991 - Elsevier
The ocular hemodynamics in diabetic patients with increasingly severe retinopathy have
been evaluated using a non-invasive computerized methodology. In a group of 19 healthy …
been evaluated using a non-invasive computerized methodology. In a group of 19 healthy …
An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and …
…, R Bonshek, GCM Black, R Grebe… - Human molecular …, 2012 - academic.oup.com
Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation.
FECD is characterized by progressive alterations in endothelial cell morphology, …
FECD is characterized by progressive alterations in endothelial cell morphology, …
[HTML][HTML] Ocular nanoparticle toxicity and transfection of the retina and retinal pigment epithelium
Chitosan (CHI), PCEP (poly {[(cholesteryl oxocarbonylamido ethyl) methyl bis (ethylene)
ammonium iodide] ethyl phosphate}), and magnetic (MNP) nanoparticles were evaluated for the …
ammonium iodide] ethyl phosphate}), and magnetic (MNP) nanoparticles were evaluated for the …
Advanced glycation endproduct-induced aging of the retinal pigment epithelium and choroid: a comprehensive transcriptional response
…, K Ishibashi, K Reiser, R Grebe… - Proceedings of the …, 2005 - National Acad Sciences
Advanced glycation endproduct (AGE) formation is a trigger for the onset of age-related
disease. To evaluate AGE-induced change in the ocular fundus, 5-mo-old C57BL/6 mice were …
disease. To evaluate AGE-induced change in the ocular fundus, 5-mo-old C57BL/6 mice were …
Lysosomes: Regulators of autophagy in the retinal pigmented epithelium
D Sinha, M Valapala, P Shang, S Hose, R Grebe… - Experimental eye …, 2016 - Elsevier
The retinal pigmented epithelium (RPE) is critically important to retinal homeostasis, in part
due to its very active processes of phagocytosis and autophagy. Both of these processes …
due to its very active processes of phagocytosis and autophagy. Both of these processes …
[HTML][HTML] PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF
…, A Zilberberg, M Idelson, B Reubinoff, R Grebe… - PLoS …, 2014 - journals.plos.org
During organogenesis, PAX6 is required for establishment of various progenitor subtypes
within the central nervous system, eye and pancreas. PAX6 expression is maintained in a …
within the central nervous system, eye and pancreas. PAX6 expression is maintained in a …