Lowering of prion protein (PrP) expression in the brain is a genetically validated therapeutic
hypothesis in prion disease. We recently showed that antisense oligonucleotide (ASO)-…

Prion disease is a fatal, incurable neurodegenerative disease of humans and other mammals
caused by conversion of cellular prion protein (PrP C) into a self-propagating neurotoxic …

Therapies currently in preclinical development for prion disease seek to lower prion protein (PrP)
expression in the brain. Trials of such therapies are likely to rely on quantification of …

Background Multiple major health organisations recommend the use of extracorporeal
membrane oxygenation (ECMO) support for COVID-19-related acute hypoxaemic respiratory …

The Beckwith-Wiedemann syndrome (BWS) is marked by fetal organ overgrowth and conveys
a predisposition to certain childhood tumors, including Wilms tumor (WT). The genetics of …

Background To examine the effects of whole body vibration (WBV) exposure on muscle
function in children with Cystic Fibrosis (CF). Non-randomised controlled cross-over trial. …

Pulmonary capillary hemangiomatosis is a rare cause of pulmonary hypertension
characterized by extensive proliferation of pulmonary capillaries within alveolar septae. Clinical …

In the United States, cytomegalovirus is the most common congenital viral infection and the
number 1 cause of nonhereditary sensorineural hearing loss. The vast majority of infants …

In research on effects of message variables, it is generally necessary to examine responses
to actual messages that represent, embody, or instantiate the values of the variable of …

As rates of childhood obesity and overweight rise around the world, researchers and policy
makers seek new ways to reverse these trends. Given the concentration of the world’s …