Resolving the DNA-binding specificities of transcription factors (TFs) is of critical value for
understanding gene regulation. Here, we present a novel, semiautomated protein–DNA …

Single-cell RNA sequencing (scRNA-seq) approaches have transformed our ability to resolve
cellular properties across systems, but are currently tailored toward large cell inputs (>…

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity 1 . However, scRNA-seq requires lysing cells, which impedes further …

Combinatorial interactions among transcription factors (TFs) play essential roles in
generating gene expression specificity and diversity in metazoans. Using yeast 2-hybrid (Y2H) …

Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment
changes over regions spanning >100 kb. These molecularly coordinated regions are …

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of
mammalian transcription factors, but most remain completely uncharacterized. While initially …

Single-cell RNA-sequencing (scRNA-seq) has revolutionized biomedical research by enabling
the in-depth analysis of cell-to-cell heterogeneity of tissues with unprecedented resolution…

Single-cell transcriptomics (scRNA-seq) has greatly advanced our ability to characterize
cellular heterogeneity in health and disease. However, scRNA-seq requires lysing cells, which …

Despite its popularity, chromatin immunoprecipitation followed by sequencing (ChIP-seq)
remains a tedious (>2 d), manually intensive, low-sensitivity and low-throughput approach. …

Background Resistance to enteric pathogens is a complex trait at the crossroads of multiple
biological processes. We have previously shown in the Drosophila Genetic Reference Panel …