User profiles for Richard C Trembath
 | Richard TrembathKing's College London Verified email at kcl.ac.uk Cited by 57296 |
Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
…, JA Phillips, JE Loyd, WC Nichols, RC Trembath - Nature …, 2000 - nature.com
Primary pulmonary hypertension (PPH), characterized by obstruction of pre-capillary pulmonary
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …
arteries, leads to sustained elevation of pulmonary arterial pressure (mean> 25 mm Hg …
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
…, JNWN Barker, GR Abecasis, JT Elder, RC Trembath - Nature …, 2012 - nature.com
To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …
of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped …
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility
Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
the spine and pelvis that occurs in approximately 5 out of 1,000 adults of European descent. …
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
…, R Allcock, P Corris, JE Loyd, RC Trembath… - Journal of medical …, 2000 - jmg.bmj.com
BACKGROUND Primary pulmonary hypertension (PPH), resulting from occlusion of small
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …
pulmonary arteries, is a devastating condition. Mutations of the bone morphogenetic protein …
[HTML][HTML] Clinical and molecular genetic features of pulmonary hypertension in patients with hereditary hemorrhagic telangiectasia
RC Trembath, JR Thomson, RD Machado… - … England Journal of …, 2001 - Mass Medical Soc
Background Most patients with familial primary pulmonary hypertension have defects in the
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
gene for bone morphogenetic protein receptor II (BMPR2), a member of the transforming …
Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension
Background— Inflammation is a feature of pulmonary arterial hypertension (PAH), and
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
increased circulating levels of cytokines are reported in patients with PAH. However, to date, no …
[HTML][HTML] Genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
…, JN Barker, L Peltonen, P Donnelly, RC Trembath - Nature …, 2010 - ncbi.nlm.nih.gov
(WTCCC2) consortia is provided in the Supplementary Note online. Author Contributions FC,
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
ADB, CEMG, J. Kere., A. Reis, JNB and RCT oversaw cohort collection for both the …
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptor
…, PD Upton, R Machado, JR Thomson, RC Trembath… - Circulation, 2002 - Am Heart Assoc
Background— Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a
receptor member of the transforming growth factor-β (TGF-β) superfamily, underlie many …
receptor member of the transforming growth factor-β (TGF-β) superfamily, underlie many …
Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
RC Trembath, R Lee Clough… - Human molecular …, 1997 - academic.oup.com
Psoriasis is a common chronic inflammatory disorder of the skin. To further understand the
pathogenesis of psoriasis we have chosen to investigate the molecular genetic basis of the …
pathogenesis of psoriasis we have chosen to investigate the molecular genetic basis of the …
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci
We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy …
disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy …