Background Encephalitis has many causes, but for most patients the cause is unknown. We
aimed to establish the cause and identify the clinical differences between causes in patients …

The 1.85 A crystal structure of endonuclease III, combined with mutational analysis,
suggests the structural basis for the DNA binding and catalytic activity of the enzyme. Helix‐hairpin‐…

Background. In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced
in the United Kingdom for those under 19 years of age. The impact of this intervention on …

Studies on the enzymology of apurinic/apyrimidinic (AP) endonucleases from procaryotic
and eucaryotic organisms are reviewed. Emphasis will be placed on the enzymes from …

THE repair of DNA requires the removal of abasic sites, which are constantly generated in
vivo both spontaneously 1 and by enzymatic removal of uracil 2 , and of bases damaged by …

The crystal structure of the DNA repair enzyme endonuclease III, which recognizes and cleaves
DNA at damaged bases, has been solved to 2.0 angstrom resolution with an R factor of …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of cancer …

Purified Escherichia coli recA protein catalyzed ATP-dependent pairing of superhelical DNA
and homologous single-stranded fragments. The product of the reaction: (i) was retained by …

5-Hydroxy-2‘-deoxycytidine (5-OHdC) and 5-hydroxy-2‘-deoxyuridine (5-OHdU) are major
products of oxidative DNA damage with mutagenic potential. Until now, no enzymatic activity …

A cloned gene, designated nfo, caused overproduction of an EDTA-resistant endonuclease
specific for apurinic-apyrimidinic sites in DNA. The sedimentation coefficient of the enzyme …