Neoplastic transformation results in a wide variety of cellular alterations that impact the growth,
survival, and general behavior of affected tissue. Although genetic alterations underpin …

The carbohydrate binding specificities of the leukoagglutinating phytohemagglutinin (L-PHA)
and erythroagglutinating phytohemagglutinin (E-PHA) lectins of the red kidney bean, …

Defined in the broadest sense, Glycobiology is the study of the structure, biosynthesis,
biology, and evolution of saccharides (sugar chains or glycans) that are widely distributed in …

Members of a family of f $ galactoside-binding lectins with related amino acid sequences,
sometimes referred to as S-type or S-Lac lectins, are found in tissues of many animals, ranging …

Neutrophils roll on P-selectin expressed by activated platelets or endothelial cells under the
shear stresses in the microcirculation. P-selectin glycoprotein ligand-1 (PSGL-1) is a high …

Glycans are among the most complex biological molecules found in nature, being composed
of monosaccharide units in various combinations and linkages, and featuring diverse and …

Leukocyte emigration into lymphatic tissues or inflammatory sites is regulated by the
expression of adhesion and signaling molecules (1). Binding of selectins to cell-surface …

P-selectin (CD62, GMP-140, PADGEM), a Ca(2+)-dependent lectin on activated platelets
and endothelium, functions as a receptor for myeloid cells by interacting with sialylated, …

A multistep series of adhesive and signaling events regulates inflammatory responses to
infection or injury (1–3). To initiate these responses, circulating leukocytes must adhere to the …

Human core 1 β3-galactosyltransferase (C1β3Gal-T) generates the core 1 O-glycan Galβ1-3GalNAcα1-Ser/Thr
(T antigen), which is a precursor for many extended O-glycans in animal …