RNA granules are structures within cells that impart key regulatory measures on gene
expression. Two general types of RNA granules are conserved from yeast to mammals: stress …

Mammalian cells form dynamic cytoplasmic mRNA stress granules (SGs) in response to
environmental stresses including viral infections. SGs are involved in regulating host mRNA …

The development of the microbiome from infancy to childhood is dependent on a range of
factors, with microbial–immune crosstalk during this time thought to be involved in the …

Poliovirus (PV) causes a rapid and drastic inhibition of host cell cap-dependent protein
synthesis during infection while preferentially allowing cap-independent translation of its own …

RIG-I-like receptors (RLRs) MDA5 and RIG-I are key players in the innate antiviral response.
Upon recognition of viral RNA, they interact with MAVS, eventually inducing type I interferon …

Viruses are implicated in autoimmune destruction of pancreatic islet β cells, which results in
insulin deficiency and type 1 diabetes (T1D) 1 , 2 , 3 – 4 . Certain enteroviruses can infect β …

Many enteroviruses, members of the familyPicornaviridae, cause a rapid and drastic inhibition
of host cell protein synthesis during infection, a process referred to as host cell shutoff. …

Cleavage of eukaryotic translation initiation factor 4GI (eIF4GI) by viral 2A protease (2Apro)
has been proposed to cause severe translation inhibition in poliovirus-infected cells. …

Virus infection initiates a number of cellular stress responses that modulate gene regulation
and compartmentalization of RNA. Viruses must control host gene expression and the …

Stress granules (SGs) are cytoplasmic storage sites containing translationally silenced mRNPs
that can be released to resume translation after stress subsides. We previously showed …