Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries…

Background Comparable data on the global and country-specific burden of neurological
disorders and their trends are crucial for health-care planning and resource allocation. The …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

Background The Millennium Declaration in 2000 brought special global attention to HIV,
tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. …

Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Background Traumatic brain injury (TBI) and spinal cord injury (SCI) are increasingly recognised
as global health priorities in view of the preventability of most injuries and the complex …

The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …

To develop a genetically faithful model of medulloblastoma with increased tumor incidence
compared with the current best model we activated the Sonic Hedgehog (Shh) pathway by …

Importance Mild traumatic brain injury (mTBI), or concussion, in children is a rapidly growing
public health concern because epidemiologic data indicate a marked increase in the …

Toward the goal of developing an optical imaging contrast agent that will enable surgeons
to intraoperatively distinguish cancer foci from adjacent normal tissue, we developed a …