THE transcription factor CREB binds to a DNA element known as the cAMP-regulated
enhancer (CRE) 1–5 . CREB is activated through phosphorylation by protein kinase A (PKA) 6 , …

CYCLIC AMP-regulated gene expression frequently involves a DNA element known as the
cAMP-regulated enhancer (CRE) 1–4 . Many transcription factors bind to this element, …

CREB binding protein (CBP) and p300 were both identified initially in protein interaction
assays–the former through its association with the transcription factor CREB (Chrivia et al. 1993…

We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat
pheochromocytoma cells transfected with the rat somatostatin gene. Forskolin at 10 microM …

THE Rubinstein-Taybi syndrome (RTS) is a well-defined syndrome with facial abnormalities,
broad thumbs, broad big toes and mental retardation as the main clinical features 1-3 . …

CREB1-binding protein (CBP) and p300 are believed to participate in the activities of hundreds
of different transcription factors (see Fig. 1). Current models suggest that the binding of …

MicroRNAs (miRNAs) regulate cellular fate by controlling the stability or translation of mRNA
transcripts. Although the spatial and temporal patterning of miRNA expression is tightly …

The CREB transcription factor regulates differentiation, survival, and synaptic plasticity. The
complement of CREB targets responsible for these responses has not been identified, …

The corepressor CtBP (carboxyl-terminal binding protein) is involved in transcriptional
pathways important for development, cell cycle regulation, and transformation. We demonstrate …

Activity-regulated gene expression is believed to play a key role in the development and
refinement of neuronal circuitry. Nevertheless, the transcriptional networks that regulate …